Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain

Sara Nasser, Aarati R. Ranade, Shravan Sridhart, Lisa Haney, Ronald L. Korn, Michael B. Gotway, Glen J. Weissy, Seungchan Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

MicroRNAs are small non-coding RNAs of 21-25 nucleotides that might impact regulatory mechanisms in cancer. Due to their influence on cell physiology, alteration of miRNA regulation can be implicated in carcinogenesis and disease progression. In general, one miRNA is predicted to regulate several hundred genes, and as a result, miRNA profiling could serve as a better classifier than gene expression profiling. More than 50% of brain metastasis (brain mets) are associated with non-small cell lung cancer (NSCLC). As miRNAs can regulate certain genes, the presence or absence of certain miRNA could lead to oncogene potential for brain mets. In this study, we combine validated miRNA expression values with imaging features to separate NSCLC brain mets from non-brain mets and identify biomarkers that may indicate possibility of brain mets. This research involves comprehensive miRNA expression profiling, validation of miRNA with qRTPCR, correlation of miRNA with imaging features such as PET/CT and CT Scan. Eleven statistically significant miRNA were identified and matched with imaging features to yield a class separation of brain mets and non-brain mets.

Original languageEnglish (US)
Title of host publication2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009
Pages246-251
Number of pages6
DOIs
StatePublished - Dec 1 2009
Event2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009 - Washington, D.C., United States
Duration: Nov 1 2009Nov 4 2009

Publication series

Name2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009

Other

Other2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009
CountryUnited States
CityWashington, D.C.
Period11/1/0911/4/09

Keywords

  • In-silico conditioning
  • Non-small cell lung cancer
  • PET/CT scan
  • miRNA

ASJC Scopus subject areas

  • Artificial Intelligence
  • Software
  • Biomedical Engineering
  • Health Informatics

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    Nasser, S., Ranade, A. R., Sridhart, S., Haney, L., Korn, R. L., Gotway, M. B., Weissy, G. J., & Kim, S. (2009). Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain. In 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009 (pp. 246-251). [5341798] (2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009). https://doi.org/10.1109/BIBM.2009.64