Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain

Sara Nasser, Aarati R. Ranade, Shravan Sridhart, Lisa Haney, Ronald L. Korn, Michael Gotway, Glen J. Weissy, Seungchan Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

MicroRNAs are small non-coding RNAs of 21-25 nucleotides that might impact regulatory mechanisms in cancer. Due to their influence on cell physiology, alteration of miRNA regulation can be implicated in carcinogenesis and disease progression. In general, one miRNA is predicted to regulate several hundred genes, and as a result, miRNA profiling could serve as a better classifier than gene expression profiling. More than 50% of brain metastasis (brain mets) are associated with non-small cell lung cancer (NSCLC). As miRNAs can regulate certain genes, the presence or absence of certain miRNA could lead to oncogene potential for brain mets. In this study, we combine validated miRNA expression values with imaging features to separate NSCLC brain mets from non-brain mets and identify biomarkers that may indicate possibility of brain mets. This research involves comprehensive miRNA expression profiling, validation of miRNA with qRTPCR, correlation of miRNA with imaging features such as PET/CT and CT Scan. Eleven statistically significant miRNA were identified and matched with imaging features to yield a class separation of brain mets and non-brain mets.

Original languageEnglish (US)
Title of host publication2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009
Pages246-251
Number of pages6
DOIs
StatePublished - 2009
Externally publishedYes
Event2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009 - Washington, D.C., United States
Duration: Nov 1 2009Nov 4 2009

Other

Other2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009
CountryUnited States
CityWashington, D.C.
Period11/1/0911/4/09

Fingerprint

MicroRNAs
Brain Neoplasms
Lung Neoplasms
Brain
Neoplasm Metastasis
Imaging techniques
Genes
Computerized tomography
Physiology
Biomarkers
Nucleotides
RNA
Gene expression
Non-Small Cell Lung Carcinoma
Classifiers
Cells
Small Untranslated RNA
Cell Physiological Phenomena
Gene Expression Profiling
Oncogenes

Keywords

  • In-silico conditioning
  • miRNA
  • Non-small cell lung cancer
  • PET/CT scan

ASJC Scopus subject areas

  • Artificial Intelligence
  • Software
  • Biomedical Engineering
  • Health Informatics

Cite this

Nasser, S., Ranade, A. R., Sridhart, S., Haney, L., Korn, R. L., Gotway, M., ... Kim, S. (2009). Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain. In 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009 (pp. 246-251). [5341798] https://doi.org/10.1109/BIBM.2009.64

Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain. / Nasser, Sara; Ranade, Aarati R.; Sridhart, Shravan; Haney, Lisa; Korn, Ronald L.; Gotway, Michael; Weissy, Glen J.; Kim, Seungchan.

2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009. 2009. p. 246-251 5341798.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nasser, S, Ranade, AR, Sridhart, S, Haney, L, Korn, RL, Gotway, M, Weissy, GJ & Kim, S 2009, Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain. in 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009., 5341798, pp. 246-251, 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009, Washington, D.C., United States, 11/1/09. https://doi.org/10.1109/BIBM.2009.64
Nasser S, Ranade AR, Sridhart S, Haney L, Korn RL, Gotway M et al. Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain. In 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009. 2009. p. 246-251. 5341798 https://doi.org/10.1109/BIBM.2009.64
Nasser, Sara ; Ranade, Aarati R. ; Sridhart, Shravan ; Haney, Lisa ; Korn, Ronald L. ; Gotway, Michael ; Weissy, Glen J. ; Kim, Seungchan. / Identifying miRNA and imaging features associated with metastasis of lung cancer to the brain. 2009 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2009. 2009. pp. 246-251
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