@article{a150e19ef6f24854b78d20f8c2abf756,
title = "Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force",
abstract = "The International Conference on Frailty and Sarcopenia Research Task Force met in March 2020, in the shadow of the COVID-19 pandemic, to discuss strategies for advancing the interdisciplinary field of geroscience. Geroscience explores biological mechanisms of aging as targets for intervention that may delay the physiological consequences of aging, maintain function, and prevent frailty and disability. Priorities for clinical practice and research include identifying and validating a range of biomarkers of the hallmarks of aging. Potential biomarkers discussed included markers of mitochondrial dysfunction, proteostasis, stem cell dysfunction, nutrient sensing, genomic instability, telomere dysfunction, cellular senescence, and epigenetic changes. The FRAILOMICS initiative is exploring many of these through various omics studies. Translating this knowledge into new therapies is being addressed by the U.S. National Institute on Aging Translational Gerontology Branch. Research gaps identified by the Task Force include the need for improved cellular and animal models as well as more reliable and sensitive measures.",
keywords = "Aging, frailty, hallmarks of aging, resilience, translational research",
author = "Lebrasseur, {Nathan K.} and {de Cabo}, R. and R. Fielding and L. Ferrucci and L. Rodriguez-Manas and J. Vi{\~n}a and B. Vellas",
note = "Funding Information: The authors thank Lisa J. Bain for assistance in the preparation of this manuscript. Dr. LeBrasseur would like to acknowledge the support of the National Institutes of Health, National Institute on Aging grants AG060907, AG055529, and AG061456. The authors are grateful to Dr. Tamara Tchkonia at Mayo Clinic for her thoughtful guidance on contents of Table . Funding Information: Conflicts of interest: NKL- none, DLW-none, MAL-none. The Task Force was partially funded by registration fees from industrial participants (Abbott Nutrition, Axcella Health, Inc, Bioage Labs, Inc, Biophytis, Cytokinetics, Danone Nutricia Research, Icon PLC, Longeveron LLC, Nestec SA). These corporations placed no restrictions on this work. Funding Information: The authors thank Lisa J. Bain for assistance in the preparation of this manuscript. Dr. LeBrasseur would like to acknowledge the support of the National Institutes of Health, National Institute on Aging grants AG060907, AG055529, and AG061456. The authors are grateful to Dr. Tamara Tchkonia at Mayo Clinic for her thoughtful guidance on contents of Table 1. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = mar,
doi = "10.14283/jfa.2021.5",
language = "English (US)",
volume = "10",
pages = "196--201",
journal = "The Journal of frailty & aging",
issn = "2260-1341",
publisher = "Serdi Publishing Company",
number = "3",
}