Identification of the molecular genetic defect of patients with methemoglobin M Kankakee (M-Iwate), α87 (F8) His → Tyr: Evidence for an electrostatic model of αM hemoglobin assembly

A. Ameri, V. F. Fairbanks, G. A. Yanik, F. Mahdi, Stephen N Thibodeau, Daniel J Mc Cormick, L. A. Boxer, K. T. McDonagh

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Abstract

We determined that the molecular defect of 2 patients with hemoglobin (Hb) M-Kankakee [Hb M-Iwate, α87 (F8) His → Tyr] resides in the α1-globin gene. The proportion of Hb M observed is higher than that predicted for an α1-globin variant. Our evidence suggests that the greater-than-expected proportion of Hb M-Kankakee results from preferential association of the electronegative β-globin chains with the α(M)-globin chains that are more electropositive than normal α-globin chains.

Original languageEnglish (US)
Pages (from-to)1825-1826
Number of pages2
JournalBlood
Volume94
Issue number5
StatePublished - Sep 1 1999

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Hemoglobin M
Methemoglobin
Globins
Static Electricity
Molecular Biology
Electrostatics
Defects
Genes

ASJC Scopus subject areas

  • Hematology

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Identification of the molecular genetic defect of patients with methemoglobin M Kankakee (M-Iwate), α87 (F8) His → Tyr : Evidence for an electrostatic model of αM hemoglobin assembly. / Ameri, A.; Fairbanks, V. F.; Yanik, G. A.; Mahdi, F.; Thibodeau, Stephen N; Mc Cormick, Daniel J; Boxer, L. A.; McDonagh, K. T.

In: Blood, Vol. 94, No. 5, 01.09.1999, p. 1825-1826.

Research output: Contribution to journalArticle

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AU - Mc Cormick, Daniel J

AU - Boxer, L. A.

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