Identification of putative nonfunctional steroid receptors in breast and endometrial cancer.

D. S. Colvard, M. L. Graham, N. J. Berg, J. N. Ingle, Daniel J Schaid, K. C. Podratz, T. C. Spelsberg

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A nuclear binding assay was developed for the purpose of having available a more predictive assay for hormone responsiveness in human cancers. The BNB assay identified specific and saturable steroid nuclear binding in human target tissues and human carcinomas. When the BNB assay was applied to a large set of breast and endometrial carcinomas, we speculate that nonfunctional receptors were detected in 20%-50% of the patients who were receptor-positive by the DCC assay. Lastly, as responsiveness to hormonal therapy in these cancer patients becomes known, the predictive value of the BNB assay can be established.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Volume118
StatePublished - 1990

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Steroid Receptors
Endometrial Neoplasms
Breast Neoplasms
Neoplasms
Steroids
Hormones
Carcinoma
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Identification of putative nonfunctional steroid receptors in breast and endometrial cancer. / Colvard, D. S.; Graham, M. L.; Berg, N. J.; Ingle, J. N.; Schaid, Daniel J; Podratz, K. C.; Spelsberg, T. C.

In: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, Vol. 118, 1990, p. 233-241.

Research output: Contribution to journalArticle

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AU - Spelsberg, T. C.

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