TY - JOUR
T1 - Identification of multiple sclerosis-associated genes
AU - Hogancamp, William E.
AU - Rodriguez, Moses
AU - Weinshenker, Brian G.
PY - 1997
Y1 - 1997
N2 - Multiple sclerosis (MS) is a complex genetic trait. Analyses to identify genetic variants that increase susceptibility to MS have primarily focused on candidate genes, either in family linkage investigations or in association (linkage disequilibrium) studies in sporadic cases and control subjects. Most of the candidate genes considered to date either influence immune function or encode structural myelin proteins. Recently, three preliminary whole genomic surveys were completed, and they reveal multiple loci of possible genetic linkage that are worthy of further study. No convincing evidence for a single strong locus has emerged from analysis of the three studies. Linkage promises to focus the future choice of candidate genes for further investigation.
AB - Multiple sclerosis (MS) is a complex genetic trait. Analyses to identify genetic variants that increase susceptibility to MS have primarily focused on candidate genes, either in family linkage investigations or in association (linkage disequilibrium) studies in sporadic cases and control subjects. Most of the candidate genes considered to date either influence immune function or encode structural myelin proteins. Recently, three preliminary whole genomic surveys were completed, and they reveal multiple loci of possible genetic linkage that are worthy of further study. No convincing evidence for a single strong locus has emerged from analysis of the three studies. Linkage promises to focus the future choice of candidate genes for further investigation.
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U2 - 10.4065/72.10.965
DO - 10.4065/72.10.965
M3 - Article
C2 - 9379703
AN - SCOPUS:0030776911
SN - 0025-6196
VL - 72
SP - 965
EP - 976
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 10
ER -