Identification of multiple genetic susceptibility loci in Takayasu arteritis

Güher Saruhan-Direskeneli, Travis Hughes, Kenan Aksu, Gokhan Keser, Patrick Coit, Sibel Z. Aydin, Fatma Alibaz-Oner, Sevil Kamali, Murat Inanc, Simon Carette, Gary S. Hoffman, Servet Akar, Fatos Onen, Nurullah Akkoc, Nader A. Khalidi, Curry Koening, Omer Karadag, Sedat Kiraz, Carol A. Langford, Carol A. McAlearZeynep Ozbalkan, Askin Ates, Yasar Karaaslan, Kathleen Maksimowicz-Mckinnon, Paul A. Monach, Hüseyin T. Ozer, Emire Seyahi, Izzet Fresko, Ayse Cefle, Philip Seo, Kenneth J Warrington, Mehmet A. Ozturk, Steven R Ytterberg, Veli Cobankara, A. Mesut Onat, Joel M. Guthridge, Judith A. James, Ercan Tunc, Nurşen Duzgun, Muge Bicakcigil, Sibel P. Yentür, Peter A. Merkel, Haner Direskeneli, Amr H. Sawalha

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is supported by the genetic association with HLA-B*52. We genotyped ∼200,000 genetic variants in two ethnically divergent Takayasu arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform (Immunochip). Additional genetic variants and the classical HLA alleles were imputed and analyzed. We identified and confirmed two independent susceptibility loci within the HLA region (r 2 < 0.2): HLA-B/MICA (rs12524487, OR = 3.29, p = 5.57 × 10-16) and HLA-DQB1/HLA-DRB1 (rs113452171, OR = 2.34, p = 3.74 × 10-9; and rs189754752, OR = 2.47, p = 4.22 × 10 -9). In addition, we identified and confirmed a genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus on chromosome 1 (rs10919543, OR = 1.81, p = 5.89 × 10-12). The risk allele in this locus results in increased mRNA expression of FCGR2A. We also established the genetic association between IL12B and Takayasu arteritis (rs56167332, OR = 1.54, p = 2.18 × 10-8).

Original languageEnglish (US)
Pages (from-to)298-305
Number of pages8
JournalAmerican Journal of Human Genetics
Volume93
Issue number2
DOIs
StatePublished - Aug 8 2013

Fingerprint

Takayasu Arteritis
Genetic Loci
Genetic Predisposition to Disease
HLA-B Antigens
Alleles
HLA-DRB1 Chains
Chromosomes, Human, Pair 1
Rare Diseases
North America
Turkey
Arteries
Messenger RNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Saruhan-Direskeneli, G., Hughes, T., Aksu, K., Keser, G., Coit, P., Aydin, S. Z., ... Sawalha, A. H. (2013). Identification of multiple genetic susceptibility loci in Takayasu arteritis. American Journal of Human Genetics, 93(2), 298-305. https://doi.org/10.1016/j.ajhg.2013.05.026

Identification of multiple genetic susceptibility loci in Takayasu arteritis. / Saruhan-Direskeneli, Güher; Hughes, Travis; Aksu, Kenan; Keser, Gokhan; Coit, Patrick; Aydin, Sibel Z.; Alibaz-Oner, Fatma; Kamali, Sevil; Inanc, Murat; Carette, Simon; Hoffman, Gary S.; Akar, Servet; Onen, Fatos; Akkoc, Nurullah; Khalidi, Nader A.; Koening, Curry; Karadag, Omer; Kiraz, Sedat; Langford, Carol A.; McAlear, Carol A.; Ozbalkan, Zeynep; Ates, Askin; Karaaslan, Yasar; Maksimowicz-Mckinnon, Kathleen; Monach, Paul A.; Ozer, Hüseyin T.; Seyahi, Emire; Fresko, Izzet; Cefle, Ayse; Seo, Philip; Warrington, Kenneth J; Ozturk, Mehmet A.; Ytterberg, Steven R; Cobankara, Veli; Onat, A. Mesut; Guthridge, Joel M.; James, Judith A.; Tunc, Ercan; Duzgun, Nurşen; Bicakcigil, Muge; Yentür, Sibel P.; Merkel, Peter A.; Direskeneli, Haner; Sawalha, Amr H.

In: American Journal of Human Genetics, Vol. 93, No. 2, 08.08.2013, p. 298-305.

Research output: Contribution to journalArticle

Saruhan-Direskeneli, G, Hughes, T, Aksu, K, Keser, G, Coit, P, Aydin, SZ, Alibaz-Oner, F, Kamali, S, Inanc, M, Carette, S, Hoffman, GS, Akar, S, Onen, F, Akkoc, N, Khalidi, NA, Koening, C, Karadag, O, Kiraz, S, Langford, CA, McAlear, CA, Ozbalkan, Z, Ates, A, Karaaslan, Y, Maksimowicz-Mckinnon, K, Monach, PA, Ozer, HT, Seyahi, E, Fresko, I, Cefle, A, Seo, P, Warrington, KJ, Ozturk, MA, Ytterberg, SR, Cobankara, V, Onat, AM, Guthridge, JM, James, JA, Tunc, E, Duzgun, N, Bicakcigil, M, Yentür, SP, Merkel, PA, Direskeneli, H & Sawalha, AH 2013, 'Identification of multiple genetic susceptibility loci in Takayasu arteritis', American Journal of Human Genetics, vol. 93, no. 2, pp. 298-305. https://doi.org/10.1016/j.ajhg.2013.05.026
Saruhan-Direskeneli G, Hughes T, Aksu K, Keser G, Coit P, Aydin SZ et al. Identification of multiple genetic susceptibility loci in Takayasu arteritis. American Journal of Human Genetics. 2013 Aug 8;93(2):298-305. https://doi.org/10.1016/j.ajhg.2013.05.026
Saruhan-Direskeneli, Güher ; Hughes, Travis ; Aksu, Kenan ; Keser, Gokhan ; Coit, Patrick ; Aydin, Sibel Z. ; Alibaz-Oner, Fatma ; Kamali, Sevil ; Inanc, Murat ; Carette, Simon ; Hoffman, Gary S. ; Akar, Servet ; Onen, Fatos ; Akkoc, Nurullah ; Khalidi, Nader A. ; Koening, Curry ; Karadag, Omer ; Kiraz, Sedat ; Langford, Carol A. ; McAlear, Carol A. ; Ozbalkan, Zeynep ; Ates, Askin ; Karaaslan, Yasar ; Maksimowicz-Mckinnon, Kathleen ; Monach, Paul A. ; Ozer, Hüseyin T. ; Seyahi, Emire ; Fresko, Izzet ; Cefle, Ayse ; Seo, Philip ; Warrington, Kenneth J ; Ozturk, Mehmet A. ; Ytterberg, Steven R ; Cobankara, Veli ; Onat, A. Mesut ; Guthridge, Joel M. ; James, Judith A. ; Tunc, Ercan ; Duzgun, Nurşen ; Bicakcigil, Muge ; Yentür, Sibel P. ; Merkel, Peter A. ; Direskeneli, Haner ; Sawalha, Amr H. / Identification of multiple genetic susceptibility loci in Takayasu arteritis. In: American Journal of Human Genetics. 2013 ; Vol. 93, No. 2. pp. 298-305.
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abstract = "Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is supported by the genetic association with HLA-B*52. We genotyped ∼200,000 genetic variants in two ethnically divergent Takayasu arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform (Immunochip). Additional genetic variants and the classical HLA alleles were imputed and analyzed. We identified and confirmed two independent susceptibility loci within the HLA region (r 2 < 0.2): HLA-B/MICA (rs12524487, OR = 3.29, p = 5.57 × 10-16) and HLA-DQB1/HLA-DRB1 (rs113452171, OR = 2.34, p = 3.74 × 10-9; and rs189754752, OR = 2.47, p = 4.22 × 10 -9). In addition, we identified and confirmed a genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus on chromosome 1 (rs10919543, OR = 1.81, p = 5.89 × 10-12). The risk allele in this locus results in increased mRNA expression of FCGR2A. We also established the genetic association between IL12B and Takayasu arteritis (rs56167332, OR = 1.54, p = 2.18 × 10-8).",
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AU - Coit, Patrick

AU - Aydin, Sibel Z.

AU - Alibaz-Oner, Fatma

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AU - Inanc, Murat

AU - Carette, Simon

AU - Hoffman, Gary S.

AU - Akar, Servet

AU - Onen, Fatos

AU - Akkoc, Nurullah

AU - Khalidi, Nader A.

AU - Koening, Curry

AU - Karadag, Omer

AU - Kiraz, Sedat

AU - Langford, Carol A.

AU - McAlear, Carol A.

AU - Ozbalkan, Zeynep

AU - Ates, Askin

AU - Karaaslan, Yasar

AU - Maksimowicz-Mckinnon, Kathleen

AU - Monach, Paul A.

AU - Ozer, Hüseyin T.

AU - Seyahi, Emire

AU - Fresko, Izzet

AU - Cefle, Ayse

AU - Seo, Philip

AU - Warrington, Kenneth J

AU - Ozturk, Mehmet A.

AU - Ytterberg, Steven R

AU - Cobankara, Veli

AU - Onat, A. Mesut

AU - Guthridge, Joel M.

AU - James, Judith A.

AU - Tunc, Ercan

AU - Duzgun, Nurşen

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