Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

Roshini S. Abraham; Chella S. David

doi:10.1016/S0952-7915(99)00060-6

Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

Roshini S. Abraham, Chella S. David

Immunology

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.

Original language	English (US)
Pages (from-to)	122-129
Number of pages	8
Journal	Current Opinion in Immunology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0952-7915(99)00060-6
State	Published - Feb 1 2000

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0952-7915(99)00060-6

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title = "Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice",

abstract = "The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.",

author = "Abraham, {Roshini S.} and David, {Chella S.}",

note = "Funding Information: Studies reported from our laboratory were supported by National Institutes of Health grants AI-14764, CA-24473 and AR-30752. Roshini S Abraham is supported by a Juvenile Diabetes Foundation International Fellowship. ",

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N2 - The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.

AB - The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.

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Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

Abstract

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