Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

Roshini S. Abraham, Chella S. David

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)122-129
Number of pages8
JournalCurrent Opinion in Immunology
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice'. Together they form a unique fingerprint.

  • Cite this