Identification of genes involved in alcohol consumption and cigarettes smoking

Mariza De Andrade, Curtis L. Olswold, Joshua P. Slusser, Larry A. Tordsen, Elizabeth J. Atkinson, Kari G. Rabe, Susan L Slager

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis using the Collaborative Study on the Genetics of Alcoholism data. We analyzed 115 extended non-Hispanic White families and tested for linkage using two phenotypes: the maximum number of drinks in a 24-hour period and the number of packs smoked per day for one year. Our results showed that the linkage signal increased using single-nucleotide polymorphisms compared with microsatellite markers and that the screening test gave similar results to that of the bivariate analysis, suggesting its potential use in reducing overall analysis time.

Original languageEnglish (US)
Article numberS112
JournalBMC Genetics
Volume6
Issue numberSUPPL.1
DOIs
StatePublished - Dec 30 2005

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Alcohol Drinking
Microsatellite Repeats
Single Nucleotide Polymorphism
Smoking
Alcoholism
Genes
Phenotype

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

De Andrade, M., Olswold, C. L., Slusser, J. P., Tordsen, L. A., Atkinson, E. J., Rabe, K. G., & Slager, S. L. (2005). Identification of genes involved in alcohol consumption and cigarettes smoking. BMC Genetics, 6(SUPPL.1), [S112]. https://doi.org/10.1186/1471-2156-6-S1-S112

Identification of genes involved in alcohol consumption and cigarettes smoking. / De Andrade, Mariza; Olswold, Curtis L.; Slusser, Joshua P.; Tordsen, Larry A.; Atkinson, Elizabeth J.; Rabe, Kari G.; Slager, Susan L.

In: BMC Genetics, Vol. 6, No. SUPPL.1, S112, 30.12.2005.

Research output: Contribution to journalArticle

De Andrade M, Olswold CL, Slusser JP, Tordsen LA, Atkinson EJ, Rabe KG et al. Identification of genes involved in alcohol consumption and cigarettes smoking. BMC Genetics. 2005 Dec 30;6(SUPPL.1). S112. https://doi.org/10.1186/1471-2156-6-S1-S112
De Andrade, Mariza ; Olswold, Curtis L. ; Slusser, Joshua P. ; Tordsen, Larry A. ; Atkinson, Elizabeth J. ; Rabe, Kari G. ; Slager, Susan L. / Identification of genes involved in alcohol consumption and cigarettes smoking. In: BMC Genetics. 2005 ; Vol. 6, No. SUPPL.1.
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