Identification of genes involved in alcohol consumption and cigarettes smoking

Mariza de Andrade; Curtis L. Olswold; Joshua P. Slusser; Larry A. Tordsen; Elizabeth J. Atkinson; Kari G. Rabe; Susan L. Slager

doi:10.1186/1471-2156-6-S1-S112

Identification of genes involved in alcohol consumption and cigarettes smoking

Mariza de Andrade, Curtis L. Olswold, Joshua P. Slusser, Larry A. Tordsen, Elizabeth J. Atkinson, Kari G. Rabe, Susan L. Slager

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis using the Collaborative Study on the Genetics of Alcoholism data. We analyzed 115 extended non-Hispanic White families and tested for linkage using two phenotypes: the maximum number of drinks in a 24-hour period and the number of packs smoked per day for one year. Our results showed that the linkage signal increased using single-nucleotide polymorphisms compared with microsatellite markers and that the screening test gave similar results to that of the bivariate analysis, suggesting its potential use in reducing overall analysis time.

Original language	English (US)
Article number	S112
Journal	BMC genetics
Volume	6
Issue number	SUPPL.1
DOIs	https://doi.org/10.1186/1471-2156-6-S1-S112
State	Published - Dec 30 2005

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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AU - de Andrade, Mariza

AU - Olswold, Curtis L.

AU - Slusser, Joshua P.

AU - Tordsen, Larry A.

AU - Atkinson, Elizabeth J.

AU - Rabe, Kari G.

AU - Slager, Susan L.

PY - 2005/12/30

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Identification of genes involved in alcohol consumption and cigarettes smoking

Abstract

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