Identification of genes involved in alcohol consumption and cigarettes smoking

Mariza de Andrade, Curtis L. Olswold, Joshua P. Slusser, Larry A. Tordsen, Elizabeth J. Atkinson, Kari G. Rabe, Susan L. Slager

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis using the Collaborative Study on the Genetics of Alcoholism data. We analyzed 115 extended non-Hispanic White families and tested for linkage using two phenotypes: the maximum number of drinks in a 24-hour period and the number of packs smoked per day for one year. Our results showed that the linkage signal increased using single-nucleotide polymorphisms compared with microsatellite markers and that the screening test gave similar results to that of the bivariate analysis, suggesting its potential use in reducing overall analysis time.

Original languageEnglish (US)
Article numberS112
JournalBMC genetics
Volume6
Issue numberSUPPL.1
DOIs
StatePublished - Dec 30 2005

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    de Andrade, M., Olswold, C. L., Slusser, J. P., Tordsen, L. A., Atkinson, E. J., Rabe, K. G., & Slager, S. L. (2005). Identification of genes involved in alcohol consumption and cigarettes smoking. BMC genetics, 6(SUPPL.1), [S112]. https://doi.org/10.1186/1471-2156-6-S1-S112