Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis

Arun Kumar, Syril Kumar Dorairaj, Venkatesh C. Prabhakaran, D. Ravi Prakash, Sanjukta Chakraborty

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Meibomian cell carcinoma (MCC) is a malignant tumor of the meibomian glands located in the eyelids. No information exists on the cytogenetic and genetic aspects of MCC. There is no report on the gene expression profile of MCC. Thus there is a need, for both scientific and clinical reasons, to identify genes and pathways that are involved in the development and progression of MCC. We analyzed the gene expression profile of MCC by the microarray technique. Forty-four genes were upregulated and 149 genes were downregulated in MCC. Differential expression data were confirmed for 5 genes by semiquantitative RT-PCR in MCC tumors: GTF2H4, RBM12, UBE2D3, DDX17, and LZTS1. We found dysregulation of two major pathways in MCC: MAPK and JAK/STAT. Clusters of genes on chromosomes 1, 12, and 19 were dysregulated in MCC. The data presented here will facilitate the identification of specific markers and therapeutic targets for the treatment of MCC patients.

Original languageEnglish (US)
Pages (from-to)559-566
Number of pages8
JournalGenomics
Volume90
Issue number5
DOIs
StatePublished - Nov 2007

Keywords

  • Expression profile
  • JAK/STAT pathway
  • MAPK signaling pathway
  • Meibomian cell carcinoma
  • Microarrays

ASJC Scopus subject areas

  • Genetics

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