Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

Rachael L. Neve, Peter C Harris, Kenneth S. Kosik, David M. Kurnit, Timothy A. Donlon

Research output: Contribution to journalArticlepeer-review

377 Scopus citations

Abstract

We have previously identified a partial human cDNA for MAP2, and we now report the isolation of human cDNA clones for tau. The RNA species recognized by the tau clones is a 6 kilobase (kb) message that is expressed in the human brain but not in other human tissues, and exhibits a developmental shift in size. We also report the human chromosomal localization of the MAP2 and tau genes. The MAP2 cDNA pKN7 was used to localize the MAP2 gene to chromosome 2q34-35. The tau cDNAs were used to confirm the presence of a tau gene on chromosome 17q21 and an additional region of homology on chromosome 6p21.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
JournalMolecular Brain Research
Volume1
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • In situ chromosome hybridization
  • Microtubule-associated protein 2
  • Neurofibrillary tangle
  • Spot-blot mapping
  • Tau gene

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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