Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

Rachael L. Neve; Peter C Harris; Kenneth S. Kosik; David M. Kurnit; Timothy A. Donlon

doi:10.1016/0169-328X(86)90033-1

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

Rachael L. Neve, Peter C Harris, Kenneth S. Kosik, David M. Kurnit, Timothy A. Donlon

Research output: Contribution to journal › Article › peer-review

390 Scopus citations

Abstract

We have previously identified a partial human cDNA for MAP2, and we now report the isolation of human cDNA clones for tau. The RNA species recognized by the tau clones is a 6 kilobase (kb) message that is expressed in the human brain but not in other human tissues, and exhibits a developmental shift in size. We also report the human chromosomal localization of the MAP2 and tau genes. The MAP2 cDNA pKN7 was used to localize the MAP2 gene to chromosome 2q34-35. The tau cDNAs were used to confirm the presence of a tau gene on chromosome 17q21 and an additional region of homology on chromosome 6p21.

Original language	English (US)
Pages (from-to)	271-280
Number of pages	10
Journal	Molecular Brain Research
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0169-328X(86)90033-1
State	Published - 1986
Externally published	Yes

Keywords

In situ chromosome hybridization
Microtubule-associated protein 2
Neurofibrillary tangle
Spot-blot mapping
Tau gene

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(86)90033-1

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title = "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2",

abstract = "We have previously identified a partial human cDNA for MAP2, and we now report the isolation of human cDNA clones for tau. The RNA species recognized by the tau clones is a 6 kilobase (kb) message that is expressed in the human brain but not in other human tissues, and exhibits a developmental shift in size. We also report the human chromosomal localization of the MAP2 and tau genes. The MAP2 cDNA pKN7 was used to localize the MAP2 gene to chromosome 2q34-35. The tau cDNAs were used to confirm the presence of a tau gene on chromosome 17q21 and an additional region of homology on chromosome 6p21.",

keywords = "In situ chromosome hybridization, Microtubule-associated protein 2, Neurofibrillary tangle, Spot-blot mapping, Tau gene",

author = "Neve, {Rachael L.} and Harris, {Peter C} and Kosik, {Kenneth S.} and Kurnit, {David M.} and Donlon, {Timothy A.}",

year = "1986",

doi = "10.1016/0169-328X(86)90033-1",

language = "English (US)",

volume = "1",

pages = "271--280",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

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TY - JOUR

T1 - Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

AU - Neve, Rachael L.

AU - Harris, Peter C

AU - Kosik, Kenneth S.

AU - Kurnit, David M.

AU - Donlon, Timothy A.

PY - 1986

Y1 - 1986

N2 - We have previously identified a partial human cDNA for MAP2, and we now report the isolation of human cDNA clones for tau. The RNA species recognized by the tau clones is a 6 kilobase (kb) message that is expressed in the human brain but not in other human tissues, and exhibits a developmental shift in size. We also report the human chromosomal localization of the MAP2 and tau genes. The MAP2 cDNA pKN7 was used to localize the MAP2 gene to chromosome 2q34-35. The tau cDNAs were used to confirm the presence of a tau gene on chromosome 17q21 and an additional region of homology on chromosome 6p21.

AB - We have previously identified a partial human cDNA for MAP2, and we now report the isolation of human cDNA clones for tau. The RNA species recognized by the tau clones is a 6 kilobase (kb) message that is expressed in the human brain but not in other human tissues, and exhibits a developmental shift in size. We also report the human chromosomal localization of the MAP2 and tau genes. The MAP2 cDNA pKN7 was used to localize the MAP2 gene to chromosome 2q34-35. The tau cDNAs were used to confirm the presence of a tau gene on chromosome 17q21 and an additional region of homology on chromosome 6p21.

KW - In situ chromosome hybridization

KW - Microtubule-associated protein 2

KW - Neurofibrillary tangle

KW - Spot-blot mapping

KW - Tau gene

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DO - 10.1016/0169-328X(86)90033-1

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JO - Brain Research

JF - Brain Research

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Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

Abstract

Keywords

ASJC Scopus subject areas

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