Identification of an atypical variant of logopenic progressive aphasia

Mary Margaret Machulda, Jennifer Lynn Whitwell, Joseph R. Duffy, Edythe A. Strand, Pamela M. Dean, Matthew L. Senjem, Clifford R Jr. Jack, Keith Anthony Josephs

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long disease duration (severe typical lvPPA). All three variants showed temporoparietal atrophy, with the mild atypical group showing the least atrophy despite the longest disease duration. The mild atypical group also showed mild neuropsychological impairment. The subjects with mild aphasia and neuropsychological impairment despite long disease duration may represent a slowly progressive variant of lvPPA.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalBrain and Language
Volume127
Issue number2
DOIs
StatePublished - Nov 2013

Fingerprint

Primary Progressive Aphasia
Aphasia
speech disorder
Atrophy
Disease
Progressive Aphasia
Cluster Analysis
cluster analysis

Keywords

  • Logopenic aphasia
  • Neurocognitive impairment
  • Primary progressive aphasia
  • Temporoparietal atrophy
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Linguistics and Language
  • Speech and Hearing
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Language and Linguistics

Cite this

Identification of an atypical variant of logopenic progressive aphasia. / Machulda, Mary Margaret; Whitwell, Jennifer Lynn; Duffy, Joseph R.; Strand, Edythe A.; Dean, Pamela M.; Senjem, Matthew L.; Jack, Clifford R Jr.; Josephs, Keith Anthony.

In: Brain and Language, Vol. 127, No. 2, 11.2013, p. 139-144.

Research output: Contribution to journalArticle

Machulda, Mary Margaret ; Whitwell, Jennifer Lynn ; Duffy, Joseph R. ; Strand, Edythe A. ; Dean, Pamela M. ; Senjem, Matthew L. ; Jack, Clifford R Jr. ; Josephs, Keith Anthony. / Identification of an atypical variant of logopenic progressive aphasia. In: Brain and Language. 2013 ; Vol. 127, No. 2. pp. 139-144.
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