Identification of an association between HLA class II alleles and low antibody levels after measles immunization

Gregory A. Poland; Inna G. Ovsyannikova; Robert M. Jacobson; Robert A. Vierkant; Steven J. Jacobsen; V. Shane Pankratz; Daniel J. Schaid

doi:10.1016/S0264-410X(01)00346-2

Identification of an association between HLA class II alleles and low antibody levels after measles immunization

Gregory A. Poland, Inna G. Ovsyannikova, Robert M. Jacobson, Robert A. Vierkant, Steven J. Jacobsen, V. Shane Pankratz, Daniel J. Schaid

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

This is the first large cohort study to report a genetic association between humoral antibody level after measles vaccine and the HLA class II genes. The WHO goal to eradicate measles world-wide magnifies the importance of data relating to the influence of immunogenetics on measles vaccine-induced antibody responses. We present here the analysis of 242 individuals who received one dose of measles-mumps-rubella-II (MMR-II) vaccine at the age of 15 months and were genotyped for HLA class II alleles. These subjects fit into one of three categories; 72 were classified as seronegative, 93 were seropositive and 77 were serohyperpositive. HLA-DRB1*03 (odds ratio (OR), 2.22) and HLA-DPA1*0201 (OR, 1.71) were significantly associated with measles vaccine seronegativity, while additional alleles provided suggestive evidence of association with seronegativity: DQA1*0201, DQB1*0201, and DQA1*0501. The alleles DRB1*03 and DQA1*0201 remained statistically significant after accounting for the effects of other alleles. These findings are crucial in designing both measles eradication by the use of vaccine, and future vaccines to be used in genetically heterozygous populations.

Original language	English (US)
Pages (from-to)	430-438
Number of pages	9
Journal	Vaccine
Volume	20
Issue number	3-4
DOIs	https://doi.org/10.1016/S0264-410X(01)00346-2
State	Published - Nov 12 2001

Keywords

Antibody response
HLA
Measles

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(01)00346-2

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title = "Identification of an association between HLA class II alleles and low antibody levels after measles immunization",

abstract = "This is the first large cohort study to report a genetic association between humoral antibody level after measles vaccine and the HLA class II genes. The WHO goal to eradicate measles world-wide magnifies the importance of data relating to the influence of immunogenetics on measles vaccine-induced antibody responses. We present here the analysis of 242 individuals who received one dose of measles-mumps-rubella-II (MMR-II) vaccine at the age of 15 months and were genotyped for HLA class II alleles. These subjects fit into one of three categories; 72 were classified as seronegative, 93 were seropositive and 77 were serohyperpositive. HLA-DRB1*03 (odds ratio (OR), 2.22) and HLA-DPA1*0201 (OR, 1.71) were significantly associated with measles vaccine seronegativity, while additional alleles provided suggestive evidence of association with seronegativity: DQA1*0201, DQB1*0201, and DQA1*0501. The alleles DRB1*03 and DQA1*0201 remained statistically significant after accounting for the effects of other alleles. These findings are crucial in designing both measles eradication by the use of vaccine, and future vaccines to be used in genetically heterozygous populations.",

keywords = "Antibody response, HLA, Measles",

author = "Poland, {Gregory A.} and Ovsyannikova, {Inna G.} and Jacobson, {Robert M.} and Vierkant, {Robert A.} and Jacobsen, {Steven J.} and Pankratz, {V. Shane} and Schaid, {Daniel J.}",

note = "Funding Information: We wish to thank the parents and children who participated in this study. We also thank Shelly K. Roberts, R.N. and Delana M. Weis, L.P.N. for their efforts in recruiting study subjects and Robert J. Fountain for his excellent technical assistance. We would like to thank Jennifer St. Sauver for critically reading the manuscript. The authors also wish to thank Erin M. Green for technical assistance. The efforts of the many fellows, technicians, nurses, and students from the Mayo Vaccine Research Group are acknowledged. This work was supported by Federal funds from the National Institute of Allergy and Infectious Diseases, NIH, under contract number NO1-AI-45240 and RO1-2AI-33144, and in part by grants HHS FD-T-000-886 and MO1 00585. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. ",

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doi = "10.1016/S0264-410X(01)00346-2",

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AU - Poland, Gregory A.

AU - Ovsyannikova, Inna G.

AU - Jacobson, Robert M.

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AU - Jacobsen, Steven J.

AU - Pankratz, V. Shane

AU - Schaid, Daniel J.

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N2 - This is the first large cohort study to report a genetic association between humoral antibody level after measles vaccine and the HLA class II genes. The WHO goal to eradicate measles world-wide magnifies the importance of data relating to the influence of immunogenetics on measles vaccine-induced antibody responses. We present here the analysis of 242 individuals who received one dose of measles-mumps-rubella-II (MMR-II) vaccine at the age of 15 months and were genotyped for HLA class II alleles. These subjects fit into one of three categories; 72 were classified as seronegative, 93 were seropositive and 77 were serohyperpositive. HLA-DRB1*03 (odds ratio (OR), 2.22) and HLA-DPA1*0201 (OR, 1.71) were significantly associated with measles vaccine seronegativity, while additional alleles provided suggestive evidence of association with seronegativity: DQA1*0201, DQB1*0201, and DQA1*0501. The alleles DRB1*03 and DQA1*0201 remained statistically significant after accounting for the effects of other alleles. These findings are crucial in designing both measles eradication by the use of vaccine, and future vaccines to be used in genetically heterozygous populations.

AB - This is the first large cohort study to report a genetic association between humoral antibody level after measles vaccine and the HLA class II genes. The WHO goal to eradicate measles world-wide magnifies the importance of data relating to the influence of immunogenetics on measles vaccine-induced antibody responses. We present here the analysis of 242 individuals who received one dose of measles-mumps-rubella-II (MMR-II) vaccine at the age of 15 months and were genotyped for HLA class II alleles. These subjects fit into one of three categories; 72 were classified as seronegative, 93 were seropositive and 77 were serohyperpositive. HLA-DRB1*03 (odds ratio (OR), 2.22) and HLA-DPA1*0201 (OR, 1.71) were significantly associated with measles vaccine seronegativity, while additional alleles provided suggestive evidence of association with seronegativity: DQA1*0201, DQB1*0201, and DQA1*0501. The alleles DRB1*03 and DQA1*0201 remained statistically significant after accounting for the effects of other alleles. These findings are crucial in designing both measles eradication by the use of vaccine, and future vaccines to be used in genetically heterozygous populations.

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Identification of an association between HLA class II alleles and low antibody levels after measles immunization

Abstract

Keywords

ASJC Scopus subject areas

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