Identification of a restriction fragment length polymorphism involving the oncogene ETS-1 on chromosome 11q23

P. D. Savage, C. A. Hanson, J. H. Kersey

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Twenty four samples of DNA from 23 unrelated individuals were analyzed for the presence of a novel restriction fragment length polymorphism (RFLP) involving the proto-oncogene ETS-1 at an Xba I site. Four samples from unrelated individuals lacked an Xba I site, giving rise to a longer restriction fragment detectable by Southern analysis; two samples were from normal tissue, and two were from acute myelogenous leukemic blasts. Thus, no association could be found between the RFLP and disease among the individuals studied. Pedigree analysis of another cohort demonstrated Mendelian inheritance consistent with a somatic polymorphism. The practical applications of RFLP analysis in clinical and research settings, and the usefulness of this Xba I RFLP in the study of hematologic malignancies because of its location in 11q23, are discussed.

Original languageEnglish (US)
Pages (from-to)327-329
Number of pages3
JournalBlood
Volume70
Issue number1
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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