Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia

Holly E. Berg, Patrick R. Blackburn, Linda B. Baughn, Rhett P. Ketterling, Xinjie Xu, Patricia T. Greipp, Nicole L. Hoppman, James B. Smadbeck, George Vasmatzis, Min Shi, Kaaren K. Reichard, David S. Viswanatha, Dragan Jevremovic, George M. Maher, Jess F. Peterson

Research output: Contribution to journalArticlepeer-review

Abstract

Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalGenes Chromosomes and Cancer
Volume60
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • GIMAP8
  • KMT2A
  • acute undifferentiated leukemia
  • mate-pair sequencing
  • next-generation sequencing

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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