Abstract
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 385-391 |
| Number of pages | 7 |
| Journal | Nature Genetics |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2013 |
ASJC Scopus subject areas
- Genetics
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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. / Eeles, Rosalind A.; Olama, Ali Amin Al; Benlloch, Sara; Saunders, Edward J.; Leongamornlert, Daniel A.; Tymrakiewicz, Malgorzata; Ghoussaini, Maya; Luccarini, Craig; Dennis, Joe; Jugurnauth-Little, Sarah; Dadaev, Tokhir; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Muir, Ken; Giles, Graham G.; Severi, Gianluca; Wiklund, Fredrik; Gronberg, Henrik; Haiman, Christopher A.; Schumacher, Fredrick; Henderson, Brian E.; Le Marchand, Loic; Lindstrom, Sara; Kraft, Peter; Hunter, David J.; Gapstur, Susan; Chanock, Stephen J.; Berndt, Sonja I.; Albanes, Demetrius; Andriole, Gerald; Schleutker, Johanna; Weischer, Maren; Canzian, Federico; Riboli, Elio; Key, Tim J.; Travis, Ruth C.; Campa, Daniele; Ingles, Sue A.; John, Esther M.; Hayes, Richard B.; Pharoah, Paul D.P.; Pashayan, Nora; Khaw, Kay Tee; Stanford, Janet L.; Ostrander, Elaine A.; Signorello, Lisa B.; Thibodeau, Stephen N.; Schaid, Dan; Maier, Christiane; Vogel, Walther; Kibel, Adam S.; Cybulski, Cezary; Lubinski, Jan; Cannon-Albright, Lisa; Brenner, Hermann; Park, Jong Y.; Kaneva, Radka; Batra, Jyotsna; Spurdle, Amanda B.; Clements, Judith A.; Teixeira, Manuel R.; Dicks, Ed; Lee, Andrew; Dunning, Alison M.; Baynes, Caroline; Conroy, Don; Maranian, Melanie J.; Ahmed, Shahana; Govindasami, Koveela; Guy, Michelle; Wilkinson, Rosemary A.; Sawyer, Emma J.; Morgan, Angela; Dearnaley, David P.; Horwich, Alan; Huddart, Robert A.; Khoo, Vincent S.; Parker, Christopher C.; Van As, Nicholas J.; Woodhouse, Christopher J.; Thompson, Alan; Dudderidge, Tim; Ogden, Chris; Cooper, Colin S.; Lophatananon, Artitaya; Cox, Angela; Southey, Melissa C.; Hopper, John L.; English, Dallas R.; Aly, Markus; Adolfsson, Jan; Xu, Jiangfeng; Zheng, Siqun L.; Yeager, Meredith; Kaaks, Rudolf; Diver, W. Ryan; Gaudet, Mia M.; Stern, Mariana C.; Corral, Roman; Joshi, Amit D.; Shahabi, Ahva; Wahlfors, Tiina; Tammela, Teuvo L.J.; Auvinen, Anssi; Virtamo, Jarmo; Klarskov, Peter; Nordestgaard, Børge G.; Røder, M. Andreas; Nielsen, Sune F.; Bojesen, Stig E.; Siddiq, Afshan; Fitzgerald, Liesel M.; Kolb, Suzanne; Kwon, Erika M.; Karyadi, Danielle M.; Blot, William J.; Zheng, Wei; Cai, Qiuyin; McDonnell, Shannon K.; Rinckleb, Antje E.; Drake, Bettina; Colditz, Graham; Wokolorczyk, Dominika; Stephenson, Robert A.; Teerlink, Craig; Muller, Heiko; Rothenbacher, Dietrich; Sellers, Thomas A.; Lin, Hui Yi; Slavov, Chavdar; Mitev, Vanio; Lose, Felicity; Srinivasan, Srilakshmi; Maia, Sofia; Paulo, Paula; Lange, Ethan; Cooney, Kathleen A.; Antoniou, Antonis C.; Vincent, Daniel; Bacot, François; Tessier, Daniel C.; Kote-Jarai, Zsofia; Easton, Douglas F.
In: Nature Genetics, Vol. 45, No. 4, 04.2013, p. 385-391.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
AU - Eeles, Rosalind A.
AU - Olama, Ali Amin Al
AU - Benlloch, Sara
AU - Saunders, Edward J.
AU - Leongamornlert, Daniel A.
AU - Tymrakiewicz, Malgorzata
AU - Ghoussaini, Maya
AU - Luccarini, Craig
AU - Dennis, Joe
AU - Jugurnauth-Little, Sarah
AU - Dadaev, Tokhir
AU - Neal, David E.
AU - Hamdy, Freddie C.
AU - Donovan, Jenny L.
AU - Muir, Ken
AU - Giles, Graham G.
AU - Severi, Gianluca
AU - Wiklund, Fredrik
AU - Gronberg, Henrik
AU - Haiman, Christopher A.
AU - Schumacher, Fredrick
AU - Henderson, Brian E.
AU - Le Marchand, Loic
AU - Lindstrom, Sara
AU - Kraft, Peter
AU - Hunter, David J.
AU - Gapstur, Susan
AU - Chanock, Stephen J.
AU - Berndt, Sonja I.
AU - Albanes, Demetrius
AU - Andriole, Gerald
AU - Schleutker, Johanna
AU - Weischer, Maren
AU - Canzian, Federico
AU - Riboli, Elio
AU - Key, Tim J.
AU - Travis, Ruth C.
AU - Campa, Daniele
AU - Ingles, Sue A.
AU - John, Esther M.
AU - Hayes, Richard B.
AU - Pharoah, Paul D.P.
AU - Pashayan, Nora
AU - Khaw, Kay Tee
AU - Stanford, Janet L.
AU - Ostrander, Elaine A.
AU - Signorello, Lisa B.
AU - Thibodeau, Stephen N.
AU - Schaid, Dan
AU - Maier, Christiane
AU - Vogel, Walther
AU - Kibel, Adam S.
AU - Cybulski, Cezary
AU - Lubinski, Jan
AU - Cannon-Albright, Lisa
AU - Brenner, Hermann
AU - Park, Jong Y.
AU - Kaneva, Radka
AU - Batra, Jyotsna
AU - Spurdle, Amanda B.
AU - Clements, Judith A.
AU - Teixeira, Manuel R.
AU - Dicks, Ed
AU - Lee, Andrew
AU - Dunning, Alison M.
AU - Baynes, Caroline
AU - Conroy, Don
AU - Maranian, Melanie J.
AU - Ahmed, Shahana
AU - Govindasami, Koveela
AU - Guy, Michelle
AU - Wilkinson, Rosemary A.
AU - Sawyer, Emma J.
AU - Morgan, Angela
AU - Dearnaley, David P.
AU - Horwich, Alan
AU - Huddart, Robert A.
AU - Khoo, Vincent S.
AU - Parker, Christopher C.
AU - Van As, Nicholas J.
AU - Woodhouse, Christopher J.
AU - Thompson, Alan
AU - Dudderidge, Tim
AU - Ogden, Chris
AU - Cooper, Colin S.
AU - Lophatananon, Artitaya
AU - Cox, Angela
AU - Southey, Melissa C.
AU - Hopper, John L.
AU - English, Dallas R.
AU - Aly, Markus
AU - Adolfsson, Jan
AU - Xu, Jiangfeng
AU - Zheng, Siqun L.
AU - Yeager, Meredith
AU - Kaaks, Rudolf
AU - Diver, W. Ryan
AU - Gaudet, Mia M.
AU - Stern, Mariana C.
AU - Corral, Roman
AU - Joshi, Amit D.
AU - Shahabi, Ahva
AU - Wahlfors, Tiina
AU - Tammela, Teuvo L.J.
AU - Auvinen, Anssi
AU - Virtamo, Jarmo
AU - Klarskov, Peter
AU - Nordestgaard, Børge G.
AU - Røder, M. Andreas
AU - Nielsen, Sune F.
AU - Bojesen, Stig E.
AU - Siddiq, Afshan
AU - Fitzgerald, Liesel M.
AU - Kolb, Suzanne
AU - Kwon, Erika M.
AU - Karyadi, Danielle M.
AU - Blot, William J.
AU - Zheng, Wei
AU - Cai, Qiuyin
AU - McDonnell, Shannon K.
AU - Rinckleb, Antje E.
AU - Drake, Bettina
AU - Colditz, Graham
AU - Wokolorczyk, Dominika
AU - Stephenson, Robert A.
AU - Teerlink, Craig
AU - Muller, Heiko
AU - Rothenbacher, Dietrich
AU - Sellers, Thomas A.
AU - Lin, Hui Yi
AU - Slavov, Chavdar
AU - Mitev, Vanio
AU - Lose, Felicity
AU - Srinivasan, Srilakshmi
AU - Maia, Sofia
AU - Paulo, Paula
AU - Lange, Ethan
AU - Cooney, Kathleen A.
AU - Antoniou, Antonis C.
AU - Vincent, Daniel
AU - Bacot, François
AU - Tessier, Daniel C.
AU - Kote-Jarai, Zsofia
AU - Easton, Douglas F.
PY - 2013/4
Y1 - 2013/4
N2 - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
AB - Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
UR - http://www.scopus.com/inward/record.url?scp=84875739291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875739291&partnerID=8YFLogxK
U2 - 10.1038/ng.2560
DO - 10.1038/ng.2560
M3 - Article
C2 - 23535732
AN - SCOPUS:84875739291
VL - 45
SP - 385
EP - 391
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -