Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind A. Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J. Saunders, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ken Muir, Graham G. Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A. HaimanFredrick Schumacher, Brian E. Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J. Hunter, Susan Gapstur, Stephen J. Chanock, Sonja I. Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J. Key, Ruth C. Travis, Daniele Campa, Sue A. Ingles, Esther M. John, Richard B. Hayes, Paul D.P. Pharoah, Nora Pashayan, Kay Tee Khaw, Janet L. Stanford, Elaine A. Ostrander, Lisa B. Signorello, Stephen N. Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S. Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-Albright, Hermann Brenner, Jong Y. Park, Radka Kaneva, Jyotsna Batra, Amanda B. Spurdle, Judith A. Clements, Manuel R. Teixeira, Ed Dicks, Andrew Lee, Alison M. Dunning, Caroline Baynes, Don Conroy, Melanie J. Maranian, Shahana Ahmed, Koveela Govindasami, Michelle Guy, Rosemary A. Wilkinson, Emma J. Sawyer, Angela Morgan, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas J. Van As, Christopher J. Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S. Cooper, Artitaya Lophatananon, Angela Cox, Melissa C. Southey, John L. Hopper, Dallas R. English, Markus Aly, Jan Adolfsson, Jiangfeng Xu, Siqun L. Zheng, Meredith Yeager, Rudolf Kaaks, W. Ryan Diver, Mia M. Gaudet, Mariana C. Stern, Roman Corral, Amit D. Joshi, Ahva Shahabi, Tiina Wahlfors, Teuvo L.J. Tammela, Anssi Auvinen, Jarmo Virtamo, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Sune F. Nielsen, Stig E. Bojesen, Afshan Siddiq, Liesel M. Fitzgerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, William J. Blot, Wei Zheng, Qiuyin Cai, Shannon K. McDonnell, Antje E. Rinckleb, Bettina Drake, Graham Colditz, Dominika Wokolorczyk, Robert A. Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Thomas A. Sellers, Hui Yi Lin, Chavdar Slavov, Vanio Mitev, Felicity Lose, Srilakshmi Srinivasan, Sofia Maia, Paula Paulo, Ethan Lange, Kathleen A. Cooney, Antonis C. Antoniou, Daniel Vincent, François Bacot, Daniel C. Tessier, Zsofia Kote-Jarai, Douglas F. Easton

Research output: Contribution to journalArticlepeer-review

378 Scopus citations

Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalNature Genetics
Volume45
Issue number4
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Genetics

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