Identification and cloning of the G3B cDNA encoding a 3′ segment of a protein binding to GATA-3

Virginia Smith Shapiro, Perry Lee, Astar Winoto

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The transcription factor GATA-3 contributes to the expression of several genes critical for T-cell function and development, including the T-cell receptor α and β chains. We report here the isolation of a human cDNA clone which encodes a 3′ segment of a novel protein with three zinc fingers. This protein, which we termed G3B, can interact with GATA-3 in vitro. Its mRNA is expressed in T and B cells. Thus, G3B may represent a potential regulator of GATA-3 function.

Original languageEnglish (US)
Pages (from-to)329-330
Number of pages2
JournalGene
Volume163
Issue number2
DOIs
StatePublished - Oct 3 1995

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Keywords

  • Recombinant DNA
  • T-cell receptor
  • transcription factor
  • zinc finger

ASJC Scopus subject areas

  • Genetics

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