Identification and cloning of the G3B cDNA encoding a 3′ segment of a protein binding to GATA-3

Virginia M Shapiro, Perry Lee, Astar Winoto

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The transcription factor GATA-3 contributes to the expression of several genes critical for T-cell function and development, including the T-cell receptor α and β chains. We report here the isolation of a human cDNA clone which encodes a 3′ segment of a novel protein with three zinc fingers. This protein, which we termed G3B, can interact with GATA-3 in vitro. Its mRNA is expressed in T and B cells. Thus, G3B may represent a potential regulator of GATA-3 function.

Original languageEnglish (US)
Pages (from-to)329-330
Number of pages2
JournalGene
Volume163
Issue number2
DOIs
StatePublished - Oct 3 1995
Externally publishedYes

Fingerprint

Protein Binding
Organism Cloning
Complementary DNA
Transcription Factor 3
T-Lymphocytes
Zinc Fingers
T-Cell Antigen Receptor
Proteins
B-Lymphocytes
Clone Cells
Gene Expression
Messenger RNA
In Vitro Techniques

Keywords

  • Recombinant DNA
  • T-cell receptor
  • transcription factor
  • zinc finger

ASJC Scopus subject areas

  • Genetics

Cite this

Identification and cloning of the G3B cDNA encoding a 3′ segment of a protein binding to GATA-3. / Shapiro, Virginia M; Lee, Perry; Winoto, Astar.

In: Gene, Vol. 163, No. 2, 03.10.1995, p. 329-330.

Research output: Contribution to journalArticle

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