Identification and characterization of the human SCAN domain zinc-finger gene ZNF449

Kuntian Luo; Jie Li; Yanhui Cui; Meng Xu; Jian Yuan; Wenwen Tang; Bo Wan; Long Yu

doi:10.1007/s11033-005-3966-0

Identification and characterization of the human SCAN domain zinc-finger gene ZNF449

Kuntian Luo, Jie Li, Yanhui Cui, Meng Xu, Jian Yuan, Wenwen Tang, Bo Wan, Long Yu

Pharmacology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C₂H₂ (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor.

Original language	English (US)
Pages (from-to)	51-57
Number of pages	7
Journal	Molecular Biology Reports
Volume	33
Issue number	1
DOIs	https://doi.org/10.1007/s11033-005-3966-0
State	Published - Mar 2006

Keywords

SCAN domain
Subcellular localization
ZNF449
Zinc-finger motif

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/s11033-005-3966-0

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title = "Identification and characterization of the human SCAN domain zinc-finger gene ZNF449",

abstract = "Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C2H2 (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor.",

keywords = "SCAN domain, Subcellular localization, ZNF449, Zinc-finger motif",

author = "Kuntian Luo and Jie Li and Yanhui Cui and Meng Xu and Jian Yuan and Wenwen Tang and Bo Wan and Long Yu",

note = "Funding Information: This work was supported by the National 973 Program, 863 High Technology Program and the National Natural Science Foundation of China.",

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doi = "10.1007/s11033-005-3966-0",

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AU - Luo, Kuntian

AU - Li, Jie

AU - Cui, Yanhui

AU - Xu, Meng

AU - Yuan, Jian

AU - Tang, Wenwen

AU - Wan, Bo

AU - Yu, Long

N1 - Funding Information: This work was supported by the National 973 Program, 863 High Technology Program and the National Natural Science Foundation of China.

PY - 2006/3

Y1 - 2006/3

N2 - Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C2H2 (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor.

AB - Zinc-finger proteins play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. In this study, we identified a gene encoding a zinc finger protein named ZNF449, which was isolated from human testis cDNA library and mapped to Xq26.3 by searching the UCSC genomic database. The ZNF449 cDNA consists of 4035 nucleotides and has a 518-amino acids open reading frame. The predicted protein contains a leucine-rich region (LER or SCAN domain) at the N-terminus. At the C-terminus of the protein, there are 7 C2H2 (Cys2-His2) zinc-finger motifs. The expression pattern of ZNF449 showed that it was ubiquitously expressed in 18 human adult tissues. ZNF449 protein was located in the nucleus when overexpressed in cultured cells. These results indicate that ZNF449 is a member of the zinc-finger family and it may function as a transcription factor.

KW - SCAN domain

KW - Subcellular localization

KW - ZNF449

KW - Zinc-finger motif

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Identification and characterization of the human SCAN domain zinc-finger gene ZNF449

Abstract

Keywords

ASJC Scopus subject areas

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