@article{4b5b4ae80f354216b09631cf08633594,
title = "Identification and characterization of a protein containing formin homology (FH1/FH2) domains",
abstract = "A novel member of the Formin/Diaphanous family of proteins was cloned and characterized. A 4 kB mRNA is ubiquitously expressed but is found in abundance in the spleen. FHOS (Formin Homologue Overexpressed in Spleen) contains a 3414 bp open reading frame and encodes for an approximately 128 kDa protein. FHOS has sequence homology to Diaphanous and Formin proteins within the Formin Homology (FH)1 and FH2 domains. FHOS also contains a coiled-coil, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. FHOS-specific antiserum was generated and used to determine that FHOS is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. FHOS was mapped to chromosome 16q22 between framework markers WI-5594 and WI-9392.",
keywords = "16q22, Diaphanous, FHOS, Formins",
author = "Westendorf, {Jennifer J.} and Ray Mernaugh and Hiebert, {Scott W.}",
note = "Funding Information: We thank Dr Shari Meyers, Dr David Strom, Dr Bart Lutterbach, Dr Randy Fenrick, Dr Joe Amann, Dr John Philips, and Dr Elizabeth Yang for many helpful discussions. The technical support of Dana King, Yue Hou, M.R.S. Krishnamani, Jennifer Watson, and Jing Wu is appreciatied. This work was supported by National Institutes of Health (NIH) grants RO1-AG13726, RO1-CA64140, and RO1-CA77274 to SWH, F32-CA77167 to JJW, and American Cancer Society grant JFRA-591 to SWH. Antibody production in the Molecular Recognition Unit of the Vanderbilt Cancer Center was supported by National Cancer Institute grant 2U01 CA61397-04. Automated sequencing and radiation hybrid panel screening in the Vanderbilt Cancer Center Genetics Shared Resource were supported by NIH grant P30-CA68485.",
year = "1999",
month = may,
day = "31",
doi = "10.1016/S0378-1119(99)00127-4",
language = "English (US)",
volume = "232",
pages = "173--182",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "2",
}