ICSH recommendations for the measurement of Haemoglobin F

A. D. Stephens; M. Angastiniotis; E. Baysal; V. Chan; B. Davis; S. Fucharoen; P. C. Giordano; J. D. Hoyer; A. Mosca; B. Wild

doi:10.1111/j.1751-553X.2011.01367.x

ICSH recommendations for the measurement of Haemoglobin F

A. D. Stephens, M. Angastiniotis, E. Baysal, V. Chan, B. Davis, S. Fucharoen, P. C. Giordano, J. D. Hoyer, A. Mosca, B. Wild

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.

Original language	English (US)
Pages (from-to)	14-20
Number of pages	7
Journal	International Journal of Laboratory Hematology
Volume	34
Issue number	1
DOIs	https://doi.org/10.1111/j.1751-553X.2011.01367.x
State	Published - Feb 2012

Keywords

Capillary electrophoresis
Haemoglobin F
Haemoglobinopathy
High-performance liquid chromatography
Recommended methods
Thalassaemia

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Biochemistry, medical

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10.1111/j.1751-553X.2011.01367.x

Cite this

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abstract = "Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.",

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AU - Stephens, A. D.

AU - Angastiniotis, M.

AU - Baysal, E.

AU - Chan, V.

AU - Davis, B.

AU - Fucharoen, S.

AU - Giordano, P. C.

AU - Hoyer, J. D.

AU - Mosca, A.

AU - Wild, B.

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AB - Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.

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KW - High-performance liquid chromatography

KW - Recommended methods

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ICSH recommendations for the measurement of Haemoglobin F

Abstract

Keywords

ASJC Scopus subject areas

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