ICSH recommendations for the measurement of Haemoglobin F

A. D. Stephens, M. Angastiniotis, E. Baysal, V. Chan, B. Davis, S. Fucharoen, P. C. Giordano, J. D. Hoyer, A. Mosca, B. Wild

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalInternational Journal of Laboratory Hematology
Volume34
Issue number1
DOIs
StatePublished - Feb 2012

Keywords

  • Capillary electrophoresis
  • Haemoglobin F
  • Haemoglobinopathy
  • High-performance liquid chromatography
  • Recommended methods
  • Thalassaemia

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Stephens, A. D., Angastiniotis, M., Baysal, E., Chan, V., Davis, B., Fucharoen, S., Giordano, P. C., Hoyer, J. D., Mosca, A., & Wild, B. (2012). ICSH recommendations for the measurement of Haemoglobin F. International Journal of Laboratory Hematology, 34(1), 14-20. https://doi.org/10.1111/j.1751-553X.2011.01367.x