ICSH recommendations for assessing automated high-performance liquid chromatography and capillary electrophoresis equipment for the quantitation of HbA2

On Behalf Of The International Council For Standardization In Haematology (ICSH)

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Automated high performance liquid chromatography and Capillary electrophoresis are used to quantitate the proportion of Hemoglobin A2 (HbA2) in blood samples order to enable screening and diagnosis of carriers of β-thalassemia. Since there is only a very small difference in HbA2 levels between people who are carriers and people who are not carriers such analyses need to be both precise and accurate. This paper examines the different parameters of such equipment and discusses how they should be assessed.

Original languageEnglish (US)
Pages (from-to)577-582
Number of pages6
JournalInternational Journal of Laboratory Hematology
Volume37
Issue number5
DOIs
StatePublished - Oct 1 2015

Keywords

  • Capillary electrophoresis
  • Hemoglobin A
  • High-performance liquid chromatography
  • β-thalassemia

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'ICSH recommendations for assessing automated high-performance liquid chromatography and capillary electrophoresis equipment for the quantitation of HbA<sub>2</sub>'. Together they form a unique fingerprint.

  • Cite this