icaA is not a useful diagnostic marker for prosthetic joint infection

Kristi L. Frank, Arlen D. Hanssen, Robin Patel

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A collection of 99 staphylococcal isolates associated with prosthetic joint infection and 23 coagulase-negative taphylococci isolated from noninfected arthroplasty-associated specimens were screened in order to determine whether the presence of icaA could be used to distinguish between pathogens and nonpathogens. All Staphylococcus aureus prosthetic joint infection isolates (n = 55) were icaA positive. A total of 46% (20 out of 44) of coagulase-negative staphylococcal prosthetic joint infection isolates were icaA positive, and 30% (7 out of 23) of arthroplasty-associated non-prosthetic joint infection-associated coagnlase-negative staphylococcal isolates were icaA positive (P = 0.23). Certain coagulase-negative Staphylococcus species appeared more likely to be isolated as either arthroplasty-associated non-prosthetic joint infection-associated isolates (e.g., Staphylococcus warnen and Staphylococcus hominis) or pathogens (e.g., Staphylococcus lugdunensis). The presence of icaA in a coagulase-negative staphylococcal isolate associated with an arthroplasty is not a useful diagnostic indicator of pathogenicity.

Original languageEnglish (US)
Pages (from-to)4846-4849
Number of pages4
JournalJournal of Clinical Microbiology
Volume42
Issue number10
DOIs
StatePublished - Oct 2004

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Coagulase
Joints
Arthroplasty
Infection
Staphylococcus
Staphylococcus hominis
Staphylococcus lugdunensis
Virulence
Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

icaA is not a useful diagnostic marker for prosthetic joint infection. / Frank, Kristi L.; Hanssen, Arlen D.; Patel, Robin.

In: Journal of Clinical Microbiology, Vol. 42, No. 10, 10.2004, p. 4846-4849.

Research output: Contribution to journalArticle

Frank, Kristi L. ; Hanssen, Arlen D. ; Patel, Robin. / icaA is not a useful diagnostic marker for prosthetic joint infection. In: Journal of Clinical Microbiology. 2004 ; Vol. 42, No. 10. pp. 4846-4849.
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