IA antigens. Genes, molecules, and function

W. P. Lafuse, C. S. David

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The class II major histocompatibility complex (MHC)1-encoded molecules in the mouse are the immune-response-associated (Ia) molecules. Ia molecules are cell surface glycoproteins consisting of two noncovalently linked polypeptide chains of 34,000 daltons (alpha chain) and 28,000 daltons (beta chain). In the mouse there are two classes of Ia molecules, I-E and I-A, each with a distinct alpha and beta chain. In contrast, in man there are three classes of class II MHC molecules, DR, DC and SB. DR molecules appear to be the equivelant of th murine I-E molecules and DC molecules appear to be the homologue of murine I-A molecules. SB molecules have insufficient homology to murine I-A or I-E molecules. Ia molecules are expressed on B cells, subpopulations of macrophages, and dendritic cells. Several functions have been mapped to the I region of the mouse: Ir gene phenomena, histocompatibility genes, and mixed lymphocytes reactivity. Recent studies have shown that these immune phenomena are all manifestations of the function of the same molecule, the Ia molecule. Although we know that Ir genes code for Ia molecules, how these molecules function in immune recognition is unclear. It is the interaction of an Ia-positive antigen-presenting cell (macrophage or B cell) with an antigen-specific T helper cell that is the key initial event in the immune response. There are currently two models to explain Ir gene responses. One model, the determinant selection model suggests that Ia molecules associate with antigen on the antigen-presenting cell surface. Ir gene defects in this model result from the failure of Ia molecules to associate with particular antigens. The second model, the clonal deletion model suggests that in nonresponder mice T cells capable of recognizing antigen in association with Ia molecules are absent. In this model T cells with affinity for self Ia antigens are removed during induction of self-tolerance. A hole in the T cell repertoire would occur if the association of foreign antigen with self-Ia molecules resembles this association of self antigen with self Ia molecules.

Original languageEnglish (US)
Pages (from-to)443-453
Number of pages11
JournalTransplantation
Volume38
Issue number5
StatePublished - 1984

Fingerprint

Histocompatibility Antigens Class II
Antigens
Genes
Antigen-Presenting Cells
Major Histocompatibility Complex
T-Lymphocytes
B-Lymphocytes
Macrophages
Clonal Deletion
Self Tolerance
Histocompatibility
Membrane Glycoproteins
Autoantigens
Helper-Inducer T-Lymphocytes
Dendritic Cells
Lymphocytes
Peptides

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Lafuse, W. P., & David, C. S. (1984). IA antigens. Genes, molecules, and function. Transplantation, 38(5), 443-453.

IA antigens. Genes, molecules, and function. / Lafuse, W. P.; David, C. S.

In: Transplantation, Vol. 38, No. 5, 1984, p. 443-453.

Research output: Contribution to journalArticle

Lafuse, WP & David, CS 1984, 'IA antigens. Genes, molecules, and function', Transplantation, vol. 38, no. 5, pp. 443-453.
Lafuse WP, David CS. IA antigens. Genes, molecules, and function. Transplantation. 1984;38(5):443-453.
Lafuse, W. P. ; David, C. S. / IA antigens. Genes, molecules, and function. In: Transplantation. 1984 ; Vol. 38, No. 5. pp. 443-453.
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