Hysteresis in the sympathetic baroreflex: Role of baseline nerve activity

Emma C. Hart, B. Gunnar Wallin, Timothy B Curry, Michael Joseph Joyner, Tomas Karlsson, Nisha Charkoudian

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Abstract

Sympathetic baroreflex sensitivity (BRS) is greater during decreasing compared to increasing diastolic blood pressure (DBP) in young men and women. In older men and women there is no difference in sympathetic BRS to increasing and decreasing DBP. We investigated whether the sensitivity of the central nervous system to increasing and decreasing DBP is dependent upon baseline muscle sympathetic nerve activity (MSNA). We hypothesised that the difference in sympathetic BRS between falling and rising segments of DBP would be positively related to baseline MSNA in 30 young men, 21 young women, 14 older men and 14 postmenopausal women. MSNA was measured using peroneal microneurography and BRS was measured using the spontaneous baroreflex threshold technique. On average, sympathetic BRS was greater during decreasing compared to increasing DBP in young men (P < 0.05) and women (P < 0.05). In older men and women, mean sympathetic BRS was similar in response to increasing and decreasing DBP. The difference (delta) between the falling and rising BRS correlated with baseline MSNA in young (r= 0.58, P < 0.05) and older men (r= 0.66, P < 0.05) and postmenopausal women (r= 0.74, P < 0.05). Thus, all men, and older women, with higher BRS to falling DBP had lower baseline MSNA. This relationship was not observed in young women (r= 0.14, P > 0.05). In summary, baseline MSNA plays a role in determining sympathetic BRS to falling and rising DBP in young and older men and postmenopausal women, but not in young women. This relationship is consistent with a decreased potential for sympathoexcitation in people with higher resting MSNA. Furthermore, the lack of relationship in young women suggests important contributions of sex hormones to differential responses of MSNA to falling and rising pressures.

Original languageEnglish (US)
Pages (from-to)3395-3404
Number of pages10
JournalJournal of Physiology
Volume589
Issue number13
DOIs
StatePublished - Jul 2011

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Baroreflex
Blood Pressure
Muscles
Gonadal Steroid Hormones
Central Nervous System

ASJC Scopus subject areas

  • Physiology

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Hysteresis in the sympathetic baroreflex : Role of baseline nerve activity. / Hart, Emma C.; Wallin, B. Gunnar; Curry, Timothy B; Joyner, Michael Joseph; Karlsson, Tomas; Charkoudian, Nisha.

In: Journal of Physiology, Vol. 589, No. 13, 07.2011, p. 3395-3404.

Research output: Contribution to journalArticle

Hart, Emma C. ; Wallin, B. Gunnar ; Curry, Timothy B ; Joyner, Michael Joseph ; Karlsson, Tomas ; Charkoudian, Nisha. / Hysteresis in the sympathetic baroreflex : Role of baseline nerve activity. In: Journal of Physiology. 2011 ; Vol. 589, No. 13. pp. 3395-3404.
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