Hypoxia and local inflammation in pulmonary artery structure and function

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hypoxia is recognized as a contributor to pulmonary vascular diseases such as pulmonary hypertension. Hypoxia-induced inflammatory changes can enhance structural and functional changes in pulmonary artery (PA) in the context of PH. Accordingly, understanding how hypoxia and inflammation are linked in the context of pulmonary artery structure and function could be relevant towards development of novel therapies for PH. In this regard, factors such as thymic stromal lymphopoietin (TSLP), an inflammatory cytokine, and brain-derived neurotrophic factor (BDNF), a neurotrophin, have been found critical for nonvascular systems such as airway and asthma. While TSLP canonically affects the immune system, in nonvascular systems, noncanonical effects such as altered [Ca2+]i and cell proliferation have been noted: aspects also relevant to the PA, where there is currently little to no data. Similarly, better known in the nervous system, there is increasing evidence that BDNF is locally produced by structural cells of the airway and can contribute to asthma pathophysiology. In this chapter, we summarize the potential relevance of factors such as TSLP and BDNF to the PA and in the context of hypoxia influences towards development of PH. We focus on cell sources and targets such as PA endothelial cells (PAECs) and smooth muscle cells (PASMCs), and the effects of TSLP or BDNF on intracellular Ca2+ responses to vasoconstrictor agonist, cell proliferation, and potential signaling cascades involved.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages325-334
Number of pages10
Volume967
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume967
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Brain-derived neurotrophic factor
  • Calcium signaling
  • Endothelial cells
  • Hypoxia
  • Pulmonary vascular disease
  • Reactive oxygen species
  • Smooth muscle cells
  • Thymic stromal lymphopoietin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Thompson, M., Britt, R. J., Pabelick, C. M., & Prakash, Y. S. (2017). Hypoxia and local inflammation in pulmonary artery structure and function. In Advances in Experimental Medicine and Biology (Vol. 967, pp. 325-334). (Advances in Experimental Medicine and Biology; Vol. 967). Springer New York LLC. https://doi.org/10.1007/978-3-319-63245-2_20