Hypothermic neuroprotection of peripheral nerve of rats from ischemia- reperfusion injury: Intraischemic vs. reperfusion hypothermia

Yoshiyuki Mitsui, James D. Schmelzer, Paula J. Zollman, Manami Mitsui, Mikihiro Kihara, Phillip A. Low

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The pathophysiology of ischemic fiber degeneration (IFD) is not known, but mechanisms involved during nerve ischemia differ from those during reperfusion. We have previously demonstrated hypothermic neuroprotection of peripheral nerve from IFD. We now evaluate the efficacy of hypothermia in the intraischemic vs. the reperfusion period, using our established model of ischemia-reperfusion injury. Intraischemic hypothermia resulted in significant recovery of all indices (behavior score, electrophysiology and histology, P < 0.01 or 0.05) while hypothermia during reperfusion period showed less improvement, significant only for the histological score compared to normothermia group (IFD index, P < 0.05). Once hypothermia was applied in the ischemic period, the resultant neuroprotection continued into the reperfusion period, even if nerve temperature was then raised during the reperfusion period. These results indicate that hypothermic neuroprotection is more efficacious during the intraischemic period than during reperfusion, when a lesser degree of neuroprotection ensued.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalBrain Research
Volume827
Issue number1-2
DOIs
StatePublished - May 8 1999

Keywords

  • Hypothermia
  • Ischemia
  • Neuroprotection
  • Peripheral nerve
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Hypothermic neuroprotection of peripheral nerve of rats from ischemia- reperfusion injury: Intraischemic vs. reperfusion hypothermia'. Together they form a unique fingerprint.

  • Cite this