Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs

Peter Y. Liu, Johannes D Veldhuis

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The function of the hypothalamo-pituitary-testicular-accessory organ axis is to ensure normal androgenization (including embryonic, infantile, pubertal, and adult sexual maturation), male sexual behavior, and reproductively competent sperm output. Thus the system is important for both the health of individuals and preservation of humankind. All elements in the system acting together as an integrative regulatory network are critical for male reproductive health. Dysfunction may result in ambiguous genitalia, sex reversal, pubertal delay, eunuchism, impaired spermatogenesis, and reduced systemic androgen exposure. Furthermore, partial deficiency of reproductive hormones may contribute to some of the features of male aging, impair recovery from protracted critical illness, and induce visceral adiposity with insulin resistance. This chapter reviews the hypothalamo-pituitary-testicular axis, its components, and their joint regulation. Where practicable, emphasis is on newer discoveries in humans. Hormonal methods to regulate male fertility and to limit age-associated frailty constitute examples of how knowledge of male reproductive physiology is being translated into clinical practice.

Original languageEnglish (US)
Title of host publicationYen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition
PublisherElsevier Inc.
Pages285-300.e8
ISBN (Electronic)9780323582322
ISBN (Print)9780323479127
DOIs
StatePublished - Feb 16 2018

Fingerprint

Testis
Eunuchism
Virilism
Disorders of Sex Development
Sexual Maturation
Reproductive Health
Adiposity
Spermatogenesis
Critical Illness
Sexual Behavior
Androgens
Fertility
Insulin Resistance
Spermatozoa
Joints
Hormones
Health

Keywords

  • Estradiol
  • Gonadotropin-releasing hormone
  • Hypothalamus
  • Kisspeptin
  • Luteinizing hormone
  • Pituitary
  • Prostate
  • Seminal vesicles
  • Testis
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, P. Y., & Veldhuis, J. D. (2018). Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs. In Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition (pp. 285-300.e8). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-47912-7.00012-3

Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs. / Liu, Peter Y.; Veldhuis, Johannes D.

Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc., 2018. p. 285-300.e8.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liu, PY & Veldhuis, JD 2018, Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs. in Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc., pp. 285-300.e8. https://doi.org/10.1016/B978-0-323-47912-7.00012-3
Liu PY, Veldhuis JD. Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs. In Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc. 2018. p. 285-300.e8 https://doi.org/10.1016/B978-0-323-47912-7.00012-3
Liu, Peter Y. ; Veldhuis, Johannes D. / Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs. Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition. Elsevier Inc., 2018. pp. 285-300.e8
@inbook{1cc03c0401874eb9889c2757399c8108,
title = "Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs",
abstract = "The function of the hypothalamo-pituitary-testicular-accessory organ axis is to ensure normal androgenization (including embryonic, infantile, pubertal, and adult sexual maturation), male sexual behavior, and reproductively competent sperm output. Thus the system is important for both the health of individuals and preservation of humankind. All elements in the system acting together as an integrative regulatory network are critical for male reproductive health. Dysfunction may result in ambiguous genitalia, sex reversal, pubertal delay, eunuchism, impaired spermatogenesis, and reduced systemic androgen exposure. Furthermore, partial deficiency of reproductive hormones may contribute to some of the features of male aging, impair recovery from protracted critical illness, and induce visceral adiposity with insulin resistance. This chapter reviews the hypothalamo-pituitary-testicular axis, its components, and their joint regulation. Where practicable, emphasis is on newer discoveries in humans. Hormonal methods to regulate male fertility and to limit age-associated frailty constitute examples of how knowledge of male reproductive physiology is being translated into clinical practice.",
keywords = "Estradiol, Gonadotropin-releasing hormone, Hypothalamus, Kisspeptin, Luteinizing hormone, Pituitary, Prostate, Seminal vesicles, Testis, Testosterone",
author = "Liu, {Peter Y.} and Veldhuis, {Johannes D}",
year = "2018",
month = "2",
day = "16",
doi = "10.1016/B978-0-323-47912-7.00012-3",
language = "English (US)",
isbn = "9780323479127",
pages = "285--300.e8",
booktitle = "Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs

AU - Liu, Peter Y.

AU - Veldhuis, Johannes D

PY - 2018/2/16

Y1 - 2018/2/16

N2 - The function of the hypothalamo-pituitary-testicular-accessory organ axis is to ensure normal androgenization (including embryonic, infantile, pubertal, and adult sexual maturation), male sexual behavior, and reproductively competent sperm output. Thus the system is important for both the health of individuals and preservation of humankind. All elements in the system acting together as an integrative regulatory network are critical for male reproductive health. Dysfunction may result in ambiguous genitalia, sex reversal, pubertal delay, eunuchism, impaired spermatogenesis, and reduced systemic androgen exposure. Furthermore, partial deficiency of reproductive hormones may contribute to some of the features of male aging, impair recovery from protracted critical illness, and induce visceral adiposity with insulin resistance. This chapter reviews the hypothalamo-pituitary-testicular axis, its components, and their joint regulation. Where practicable, emphasis is on newer discoveries in humans. Hormonal methods to regulate male fertility and to limit age-associated frailty constitute examples of how knowledge of male reproductive physiology is being translated into clinical practice.

AB - The function of the hypothalamo-pituitary-testicular-accessory organ axis is to ensure normal androgenization (including embryonic, infantile, pubertal, and adult sexual maturation), male sexual behavior, and reproductively competent sperm output. Thus the system is important for both the health of individuals and preservation of humankind. All elements in the system acting together as an integrative regulatory network are critical for male reproductive health. Dysfunction may result in ambiguous genitalia, sex reversal, pubertal delay, eunuchism, impaired spermatogenesis, and reduced systemic androgen exposure. Furthermore, partial deficiency of reproductive hormones may contribute to some of the features of male aging, impair recovery from protracted critical illness, and induce visceral adiposity with insulin resistance. This chapter reviews the hypothalamo-pituitary-testicular axis, its components, and their joint regulation. Where practicable, emphasis is on newer discoveries in humans. Hormonal methods to regulate male fertility and to limit age-associated frailty constitute examples of how knowledge of male reproductive physiology is being translated into clinical practice.

KW - Estradiol

KW - Gonadotropin-releasing hormone

KW - Hypothalamus

KW - Kisspeptin

KW - Luteinizing hormone

KW - Pituitary

KW - Prostate

KW - Seminal vesicles

KW - Testis

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=85046607357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046607357&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-47912-7.00012-3

DO - 10.1016/B978-0-323-47912-7.00012-3

M3 - Chapter

SN - 9780323479127

SP - 285-300.e8

BT - Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition

PB - Elsevier Inc.

ER -