Hypopituitarism caused by intrasellar aneurysms

Hassan M. Heshmati, Vahab Fatourechi, Shekhar A. Dagam, David G. Piepgras

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: To determine the prevalence, clinical presentation, and outcome of hypopituitarism due to an intrasellar aneurysm. Patients and Methods: We performed a retrospective review of Mayo Clinic, Rochester, Minn, medical records from 1950 through 1995. We calculated the prevalence of hypopituitarism, characterized the clinical presentation, and evaluated postoperative outcomes. Results: Of 4087 patients with a diagnosis of hypopituitarism, 7 had hypopituitarism due to an intrasellar aneurysm, accounting for a prevalence of 0.17%. Adrenal, thyroid, and gonadal deficiencies were observed in 7, 6, and 5 patients, respectively. The prolactin level was increased in the 2 patients in whom it was measured. No patient had diabetes insipidus. All had visual impairment. In 5 patients an intrasellar aneurysm of the internal carotid artery was diagnosed preoperatively based on 1 or more imaging procedures. In the other 2 patients (1 with an internal carotid artery aneurysm and 1 with an anterior cerebral artery aneurysm), the diagnosis was made at surgical exploration. Four patients underwent a surgical procedure: 2 had direct packing of the aneurysm, and 2 had a bypass with proximal carotid occlusion or aneurysm trapping. Pituitary function remained unchanged postoperatively. Conclusion: An intrasellar aneurysm is a rare cause of hypopituitarism (0.17% of cases). Preoperative diagnosis is essential for successful surgical outcomes. Hypopituitarism is usually permanent.

Original languageEnglish (US)
Article number63222
Pages (from-to)789-793
Number of pages5
JournalMayo Clinic proceedings
Volume76
Issue number8
DOIs
StatePublished - Jan 1 2001

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Hypopituitarism
Aneurysm
Internal Carotid Artery
Diabetes Insipidus
Vision Disorders
Intracranial Aneurysm
Prolactin
Medical Records
Thyroid Gland

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Heshmati, H. M., Fatourechi, V., Dagam, S. A., & Piepgras, D. G. (2001). Hypopituitarism caused by intrasellar aneurysms. Mayo Clinic proceedings, 76(8), 789-793. [63222]. https://doi.org/10.4065/76.8.789

Hypopituitarism caused by intrasellar aneurysms. / Heshmati, Hassan M.; Fatourechi, Vahab; Dagam, Shekhar A.; Piepgras, David G.

In: Mayo Clinic proceedings, Vol. 76, No. 8, 63222, 01.01.2001, p. 789-793.

Research output: Contribution to journalArticle

Heshmati, HM, Fatourechi, V, Dagam, SA & Piepgras, DG 2001, 'Hypopituitarism caused by intrasellar aneurysms', Mayo Clinic proceedings, vol. 76, no. 8, 63222, pp. 789-793. https://doi.org/10.4065/76.8.789
Heshmati, Hassan M. ; Fatourechi, Vahab ; Dagam, Shekhar A. ; Piepgras, David G. / Hypopituitarism caused by intrasellar aneurysms. In: Mayo Clinic proceedings. 2001 ; Vol. 76, No. 8. pp. 789-793.
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