TY - JOUR
T1 - Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired Von Willebrand syndrome
T2 - Response to septal myectomy
AU - Blackshear, Joseph L.
AU - Schaff, Hartzell V.
AU - Ommen, Steve R.
AU - Chen, Dong
AU - Nichols, William L.
PY - 2011/3
Y1 - 2011/3
N2 - Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome.
AB - Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome.
UR - http://www.scopus.com/inward/record.url?scp=79952403228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952403228&partnerID=8YFLogxK
U2 - 10.4065/mcp.2010.0309
DO - 10.4065/mcp.2010.0309
M3 - Article
C2 - 21364113
AN - SCOPUS:79952403228
SN - 0025-6196
VL - 86
SP - 219
EP - 224
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 3
ER -