Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired Von Willebrand syndrome: Response to septal myectomy

Joseph L. Blackshear, Hartzell V. Schaff, Steve R. Ommen, Dong Chen, William L. Nichols

Research output: Contribution to journalArticle

30 Scopus citations


Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalMayo Clinic proceedings
Issue number3
StatePublished - Mar 2011


ASJC Scopus subject areas

  • Medicine(all)

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