Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired Von Willebrand syndrome: Response to septal myectomy

Joseph L. Blackshear, Hartzell V Schaff, Steve R. Ommen, Dong Chen, William L. Nichols

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalMayo Clinic Proceedings
Volume86
Issue number3
DOIs
StatePublished - 2011

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Hypertrophic Cardiomyopathy
Hemorrhage
Molecular Weight
Aortic Valve Stenosis
von Willebrand Factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired Von Willebrand syndrome : Response to septal myectomy. / Blackshear, Joseph L.; Schaff, Hartzell V; Ommen, Steve R.; Chen, Dong; Nichols, William L.

In: Mayo Clinic Proceedings, Vol. 86, No. 3, 2011, p. 219-224.

Research output: Contribution to journalArticle

Blackshear, Joseph L. ; Schaff, Hartzell V ; Ommen, Steve R. ; Chen, Dong ; Nichols, William L. / Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired Von Willebrand syndrome : Response to septal myectomy. In: Mayo Clinic Proceedings. 2011 ; Vol. 86, No. 3. pp. 219-224.
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