Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists

Rebecca S. Bahn, Henry B. Burch, David S. Cooper, Jeffrey R. Garber, M. Carol Greenlee, Irwin Klein, Peter Laurberg, I. Ross McDougall, Victor Manuel Montori, Scott A. Rivkees, Douglas S. Ross, Julie Ann Sosa, Marius N. Stan

Research output: Contribution to journalArticle

486 Citations (Scopus)

Abstract

Background: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This article describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspeciality physicians and others providing care for patients with this condition. Methods: The development of these guidelines was commissioned by the American Thyroid Association in association with the American Association of Clinical Endocrinologists. The American Thyroid Association and American Association of Clinical Endocrinologists assembled a task force of expert clinicians who authored this report. The task force examined relevant literature using a systematic PubMed search supplemented with additional published materials. An evidence-based medicine approach that incorporated the knowledge and experience of the panel was used to develop the text and a series of specific recommendations. The strength of the recommendations and the quality of evidence supporting each was rated according to the approach recommended by the Grading of Recommendations, Assessment, Development, and Evaluation Group. Results: Clinical topics addressed include the initial evaluation and management of thyrotoxicosis; management of Graves' hyperthyroidism using radioactive iodine, antithyroid drugs, or surgery; management of toxic multinodular goiter or toxic adenoma using radioactive iodine or surgery; Graves' disease in children, adolescents, or pregnant patients; subclinical hyperthyroidism; hyperthyroidism in patients with Graves' ophthalmopathy; and management of other miscellaneous causes of thyrotoxicosis. Conclusions: One hundred evidence-based recommendations were developed to aid in the care of patients with thyrotoxicosis and to share what the task force believes is current, rational, and optimal medical practice.

Original languageEnglish (US)
Pages (from-to)593-646
Number of pages54
JournalThyroid
Volume21
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Thyrotoxicosis
Hyperthyroidism
Guidelines
Advisory Committees
Poisons
Iodine
Patient Care
Graves Ophthalmopathy
Antithyroid Agents
Patient Preference
Evidence-Based Medicine
Graves Disease
Goiter
PubMed
Adenoma
Physicians
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Hyperthyroidism and other causes of thyrotoxicosis : Management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. / Bahn, Rebecca S.; Burch, Henry B.; Cooper, David S.; Garber, Jeffrey R.; Greenlee, M. Carol; Klein, Irwin; Laurberg, Peter; McDougall, I. Ross; Montori, Victor Manuel; Rivkees, Scott A.; Ross, Douglas S.; Sosa, Julie Ann; Stan, Marius N.

In: Thyroid, Vol. 21, No. 6, 01.06.2011, p. 593-646.

Research output: Contribution to journalArticle

Bahn, RS, Burch, HB, Cooper, DS, Garber, JR, Greenlee, MC, Klein, I, Laurberg, P, McDougall, IR, Montori, VM, Rivkees, SA, Ross, DS, Sosa, JA & Stan, MN 2011, 'Hyperthyroidism and other causes of thyrotoxicosis: Management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists', Thyroid, vol. 21, no. 6, pp. 593-646. https://doi.org/10.1089/thy.2010.0417
Bahn, Rebecca S. ; Burch, Henry B. ; Cooper, David S. ; Garber, Jeffrey R. ; Greenlee, M. Carol ; Klein, Irwin ; Laurberg, Peter ; McDougall, I. Ross ; Montori, Victor Manuel ; Rivkees, Scott A. ; Ross, Douglas S. ; Sosa, Julie Ann ; Stan, Marius N. / Hyperthyroidism and other causes of thyrotoxicosis : Management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. In: Thyroid. 2011 ; Vol. 21, No. 6. pp. 593-646.
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AU - Klein, Irwin

AU - Laurberg, Peter

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AU - Montori, Victor Manuel

AU - Rivkees, Scott A.

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AU - Sosa, Julie Ann

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