TY - JOUR
T1 - Hypertension in pregnancy and future cardiovascular event risk in siblings
AU - Weissgerber, Tracey L.
AU - Turner, Stephen T.
AU - Mosley, Thomas H.
AU - Kardia, Sharon L.R.
AU - Hanis, Craig L.
AU - Milic, Natasa M.
AU - Garovic, Vesna D.
N1 - Funding Information:
GENOAwas supported by grants from the National Heart, Lung, and Blood Institute and National Institutes of Health (NIH) (U01-HL054481, U01-HL054471, U01-HL054512, and U01-HL054498). This secondary analysis was supported by award number P-50 AG44170 (V.D. Garovic) from the National Institute on Aging. T.L.W. was supported by the Office of Women''s Health Research (Building Interdisciplinary Careers in Women''s Health award K12-HD065987). This publication was made possible by CTSA grant number UL1-TR000135 from the National Center for Advancing Translational Sciences (NCATS), a component of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The writing of the manuscript and the decision to submit it for publication were solely the authors'' responsibilities. This work has previously been published as an abstract (Reproductive Sciences, 21(3S):381A, 2014).
PY - 2016/3
Y1 - 2016/3
N2 - Hypertension in pregnancy is a risk factor for future hypertension and cardiovascular disease. This may reflect an underlying familial predisposition or persistent damage caused by the hypertensive pregnancy. We sought to isolate the effect of hypertension in pregnancy by comparing the risk of hypertension and cardiovascular disease in women who had hypertension in pregnancy and their sisters who did not using the dataset from the Genetic Epidemiology Network of Arteriopathy study, which examined the genetics of hypertension in white, black, and Hispanic siblings. This analysis included all sibships with at least one parous woman and at least one other sibling. After gathering demographic and pregnancy data, BP and serum analytes were measured. Disease-free survival was examined using Kaplan-Meier curves and Cox proportional hazards regression.Comparedwith their sisterswho did not have hypertension in pregnancy, women who had hypertension in pregnancy were more likely to develop new onset hypertension later in life, after adjusting for body mass index and diabetes (hazard ratio 1.75, 95% confidence interval 1.27-2.42). A sibling history of hypertension in pregnancy was also associated with an increased risk of hypertension in brothers and unaffected sisters, whereas an increased risk of cardiovascular events was observed in brothers only. These results suggest familial factors contribute to the increased risk of future hypertension in women who had hypertension in pregnancy. Further studies are needed to clarify the potential role of nonfamilial factors. Furthermore, a sibling history of hypertension in pregnancy may be a novel familial risk factor for future hypertension.
AB - Hypertension in pregnancy is a risk factor for future hypertension and cardiovascular disease. This may reflect an underlying familial predisposition or persistent damage caused by the hypertensive pregnancy. We sought to isolate the effect of hypertension in pregnancy by comparing the risk of hypertension and cardiovascular disease in women who had hypertension in pregnancy and their sisters who did not using the dataset from the Genetic Epidemiology Network of Arteriopathy study, which examined the genetics of hypertension in white, black, and Hispanic siblings. This analysis included all sibships with at least one parous woman and at least one other sibling. After gathering demographic and pregnancy data, BP and serum analytes were measured. Disease-free survival was examined using Kaplan-Meier curves and Cox proportional hazards regression.Comparedwith their sisterswho did not have hypertension in pregnancy, women who had hypertension in pregnancy were more likely to develop new onset hypertension later in life, after adjusting for body mass index and diabetes (hazard ratio 1.75, 95% confidence interval 1.27-2.42). A sibling history of hypertension in pregnancy was also associated with an increased risk of hypertension in brothers and unaffected sisters, whereas an increased risk of cardiovascular events was observed in brothers only. These results suggest familial factors contribute to the increased risk of future hypertension in women who had hypertension in pregnancy. Further studies are needed to clarify the potential role of nonfamilial factors. Furthermore, a sibling history of hypertension in pregnancy may be a novel familial risk factor for future hypertension.
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U2 - 10.1681/ASN.2015010086
DO - 10.1681/ASN.2015010086
M3 - Article
C2 - 26315531
AN - SCOPUS:84959918134
SN - 1046-6673
VL - 27
SP - 894
EP - 902
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 3
ER -