Hypersensitivity myocarditis in heart transplant candidates

M. B. Gravanis, G. L. Hertzler, R. H. Franch, L. D. Stacy, A. A. Ansari, K. R. Kanter, H. D. Tazelaar, R. Rodeheffer, C. McGregor

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Hypersensitivity myocarditis is a rare event; however, routine histologic examination of all (193) explanted hearts for heart transplantation in our institutions revealed hypersensitivity myocarditis in 15 patients (7%). This is a previously unreported finding in heart transplant recipients. None of the cases was detected clinically, although all manifested peripheral eosinophilia at some point during the 2 weeks before transplantation. Only one patient exhibited a skin rash interpreted as allergic. The severity of the interstitial infiltrate varied from grade I to grade IV (semiquantitative). This group of pretransplantation patients was receiving a multiplicity of drugs, some of which could have potentially triggered the hypersensitivity myocarditis, although in only one case was a definite association between a hypersensitivity reaction and a drug made. The unusually high rate (10.3% for the Emory cases) of drug-induced myocarditis in this group of patients, contrasted with the general autopsy population, probably reflects that these patients received more vigorous than usual drug treatment, particularly antibiotics, to sustain them until a suitable donor was found.

Original languageEnglish (US)
Pages (from-to)688-697
Number of pages10
JournalJournal of Heart and Lung Transplantation
Volume10
Issue number5 I
StatePublished - 1991
Externally publishedYes

Fingerprint

Myocarditis
Hypersensitivity
Transplants
Pharmaceutical Preparations
Eosinophilia
Heart Transplantation
Exanthema
Autopsy
Transplantation
Tissue Donors
Anti-Bacterial Agents
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Gravanis, M. B., Hertzler, G. L., Franch, R. H., Stacy, L. D., Ansari, A. A., Kanter, K. R., ... McGregor, C. (1991). Hypersensitivity myocarditis in heart transplant candidates. Journal of Heart and Lung Transplantation, 10(5 I), 688-697.

Hypersensitivity myocarditis in heart transplant candidates. / Gravanis, M. B.; Hertzler, G. L.; Franch, R. H.; Stacy, L. D.; Ansari, A. A.; Kanter, K. R.; Tazelaar, H. D.; Rodeheffer, R.; McGregor, C.

In: Journal of Heart and Lung Transplantation, Vol. 10, No. 5 I, 1991, p. 688-697.

Research output: Contribution to journalArticle

Gravanis, MB, Hertzler, GL, Franch, RH, Stacy, LD, Ansari, AA, Kanter, KR, Tazelaar, HD, Rodeheffer, R & McGregor, C 1991, 'Hypersensitivity myocarditis in heart transplant candidates', Journal of Heart and Lung Transplantation, vol. 10, no. 5 I, pp. 688-697.
Gravanis MB, Hertzler GL, Franch RH, Stacy LD, Ansari AA, Kanter KR et al. Hypersensitivity myocarditis in heart transplant candidates. Journal of Heart and Lung Transplantation. 1991;10(5 I):688-697.
Gravanis, M. B. ; Hertzler, G. L. ; Franch, R. H. ; Stacy, L. D. ; Ansari, A. A. ; Kanter, K. R. ; Tazelaar, H. D. ; Rodeheffer, R. ; McGregor, C. / Hypersensitivity myocarditis in heart transplant candidates. In: Journal of Heart and Lung Transplantation. 1991 ; Vol. 10, No. 5 I. pp. 688-697.
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