Hyperoxaluria and urolithiasis in young children: An atypical presentation

Carla G. Monico, Dawn S. Milliner

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Urolithiasis is uncommon in adolescence and rare in early childhood. In pediatric populations, congenital urinary tract anomalies associated with stasis and infection, idiopathic urolithiasis (adolescents), and nephrocalcinosis (premature infants) account for the majority of urolithiasis patients. Inborn errors of metabolism, such as the primary hyperoxalurias, are rare causes of urolithiasis in childhood. We report six children (mean age at symptom onset 1.3 years; range 0.32-4.1 years) with moderate hyperoxaluria (mean 1,10 ± 0.58 mmoL/1.73m2 per day; range 0.69-2.19 mmoL/1.73m2 per day). Urolithiasis was present in four. Stones from two children were comprised of calcium oxalate dihydrate. Calcium oxalate crystalluria was seen in two of the patients. Findings included a mean urine calcium concentration of 6.61 ± 2.28 mg/kg per day, urine citrate of 925.5 ± 291.29 mg/g of creatinine per day, and mean renal clearance of 99.83 ± 23.27 mL/min. All children were born full term, none was receiving diuretics, and none had recurrent urinary tract infections. Secondary causes of hyperoxaluria, including dietary oxalate excess, pyridoxine deficiency, and malabsorption, were excluded. Urine glycolate and glycerate were normal in all patients. In one hyperoxaluric member of each sibship, hepatic alanine- glyoxylate aminotransferase and D-glycerate dehydrogenase/glyoxylate reductase activity were normal. The clinical and biochemical features of these children are unlike those in previously recognized hyperoxaluric states. Thus, our description of a separate hyperoxaluric entity, referred to as unclassified hyperoxaluria.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalJournal of Endourology
Volume13
Issue number9
StatePublished - 1999

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Hyperoxaluria
Urolithiasis
Calcium Oxalate
glycolic acid
glyoxylate reductase
Urine
Glycerate dehydrogenase
Primary Hyperoxaluria
Vitamin B 6 Deficiency
Nephrocalcinosis
Inborn Errors Metabolism
Oxalates
Urinary Tract
Age of Onset
Diuretics
Premature Infants
Urinary Tract Infections
Citric Acid
Creatinine
Pediatrics

ASJC Scopus subject areas

  • Urology

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Hyperoxaluria and urolithiasis in young children : An atypical presentation. / Monico, Carla G.; Milliner, Dawn S.

In: Journal of Endourology, Vol. 13, No. 9, 1999, p. 633-636.

Research output: Contribution to journalArticle

Monico, CG & Milliner, DS 1999, 'Hyperoxaluria and urolithiasis in young children: An atypical presentation', Journal of Endourology, vol. 13, no. 9, pp. 633-636.
Monico, Carla G. ; Milliner, Dawn S. / Hyperoxaluria and urolithiasis in young children : An atypical presentation. In: Journal of Endourology. 1999 ; Vol. 13, No. 9. pp. 633-636.
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