Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma

Thomas W. Link, Graeme F. Woodworth, Kaisorn L. Chaichana, Stuart A. Grossman, Robert S. Mayer, Henry Brem, Jon D. Weingart, Alfredo Quinones-Hinojosa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The poor prognosis for patients with glioblastoma (GB) heightens the importance of maintaining function throughout treatment. Hyperglycemia has been linked to poor neurological outcomes following stroke, traumatic brain and spinal cord injury. We hypothesized this may also be true following the resection of GB. We assessed associations with post-operative function with the goal of identifying modifiable factors in the peri-operative period with a particular focus on blood glucose levels. Independent associations with worse post-operative function included: patient age, pre-operative motor deficit, deep tumor location, post-operative motor deficit, and elevated mean peri-operative glucose. Interestingly, controlling for associated factors including dexamethasone dosing, patients with elevated peri-operative glucose levels were nearly twice as likely to have new post-operative neurological deficits. These results suggest, together with the broad literature supporting a role for hyperglycemia in neurological injury, that this may represent a modifiable factor in the peri-operative care of these patients.

Original languageEnglish (US)
Pages (from-to)996-1000
Number of pages5
JournalJournal of Clinical Neuroscience
Volume19
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

Fingerprint

Glioblastoma
Hyperglycemia
Glucose
Spinal Cord Injuries
Dexamethasone
Blood Glucose
Patient Care
Stroke
Wounds and Injuries
Brain
Neoplasms
Therapeutics

Keywords

  • Function
  • Glioblastoma
  • Hyperglycemia
  • Rehabilitation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Cite this

Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma. / Link, Thomas W.; Woodworth, Graeme F.; Chaichana, Kaisorn L.; Grossman, Stuart A.; Mayer, Robert S.; Brem, Henry; Weingart, Jon D.; Quinones-Hinojosa, Alfredo.

In: Journal of Clinical Neuroscience, Vol. 19, No. 7, 07.2012, p. 996-1000.

Research output: Contribution to journalArticle

Link, Thomas W. ; Woodworth, Graeme F. ; Chaichana, Kaisorn L. ; Grossman, Stuart A. ; Mayer, Robert S. ; Brem, Henry ; Weingart, Jon D. ; Quinones-Hinojosa, Alfredo. / Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma. In: Journal of Clinical Neuroscience. 2012 ; Vol. 19, No. 7. pp. 996-1000.
@article{4edbe2aa478546f78de21090b1cd0269,
title = "Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma",
abstract = "The poor prognosis for patients with glioblastoma (GB) heightens the importance of maintaining function throughout treatment. Hyperglycemia has been linked to poor neurological outcomes following stroke, traumatic brain and spinal cord injury. We hypothesized this may also be true following the resection of GB. We assessed associations with post-operative function with the goal of identifying modifiable factors in the peri-operative period with a particular focus on blood glucose levels. Independent associations with worse post-operative function included: patient age, pre-operative motor deficit, deep tumor location, post-operative motor deficit, and elevated mean peri-operative glucose. Interestingly, controlling for associated factors including dexamethasone dosing, patients with elevated peri-operative glucose levels were nearly twice as likely to have new post-operative neurological deficits. These results suggest, together with the broad literature supporting a role for hyperglycemia in neurological injury, that this may represent a modifiable factor in the peri-operative care of these patients.",
keywords = "Function, Glioblastoma, Hyperglycemia, Rehabilitation",
author = "Link, {Thomas W.} and Woodworth, {Graeme F.} and Chaichana, {Kaisorn L.} and Grossman, {Stuart A.} and Mayer, {Robert S.} and Henry Brem and Weingart, {Jon D.} and Alfredo Quinones-Hinojosa",
year = "2012",
month = "7",
doi = "10.1016/j.jocn.2011.09.031",
language = "English (US)",
volume = "19",
pages = "996--1000",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",
number = "7",

}

TY - JOUR

T1 - Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma

AU - Link, Thomas W.

AU - Woodworth, Graeme F.

AU - Chaichana, Kaisorn L.

AU - Grossman, Stuart A.

AU - Mayer, Robert S.

AU - Brem, Henry

AU - Weingart, Jon D.

AU - Quinones-Hinojosa, Alfredo

PY - 2012/7

Y1 - 2012/7

N2 - The poor prognosis for patients with glioblastoma (GB) heightens the importance of maintaining function throughout treatment. Hyperglycemia has been linked to poor neurological outcomes following stroke, traumatic brain and spinal cord injury. We hypothesized this may also be true following the resection of GB. We assessed associations with post-operative function with the goal of identifying modifiable factors in the peri-operative period with a particular focus on blood glucose levels. Independent associations with worse post-operative function included: patient age, pre-operative motor deficit, deep tumor location, post-operative motor deficit, and elevated mean peri-operative glucose. Interestingly, controlling for associated factors including dexamethasone dosing, patients with elevated peri-operative glucose levels were nearly twice as likely to have new post-operative neurological deficits. These results suggest, together with the broad literature supporting a role for hyperglycemia in neurological injury, that this may represent a modifiable factor in the peri-operative care of these patients.

AB - The poor prognosis for patients with glioblastoma (GB) heightens the importance of maintaining function throughout treatment. Hyperglycemia has been linked to poor neurological outcomes following stroke, traumatic brain and spinal cord injury. We hypothesized this may also be true following the resection of GB. We assessed associations with post-operative function with the goal of identifying modifiable factors in the peri-operative period with a particular focus on blood glucose levels. Independent associations with worse post-operative function included: patient age, pre-operative motor deficit, deep tumor location, post-operative motor deficit, and elevated mean peri-operative glucose. Interestingly, controlling for associated factors including dexamethasone dosing, patients with elevated peri-operative glucose levels were nearly twice as likely to have new post-operative neurological deficits. These results suggest, together with the broad literature supporting a role for hyperglycemia in neurological injury, that this may represent a modifiable factor in the peri-operative care of these patients.

KW - Function

KW - Glioblastoma

KW - Hyperglycemia

KW - Rehabilitation

UR - http://www.scopus.com/inward/record.url?scp=84862173557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862173557&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2011.09.031

DO - 10.1016/j.jocn.2011.09.031

M3 - Article

C2 - 22595358

AN - SCOPUS:84862173557

VL - 19

SP - 996

EP - 1000

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

IS - 7

ER -