Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii

Katarina Šavikin-Fodulović, Ivana Aljančić, Vlatka Vajs, Nebojša Menković, Slobodan Macura, Gordana Gojgić, Slobodan Milosavljević

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

As shown by quantitative 1H NMR measurements, a lipophilic extract of the aerial parts of Hypericum atomarium ssp. degenii contained a high percentage (3.1% per weight of dried plant material) of a prenylated phloroglucinol (1). Compound 1, named hyperatomarin, occurring in two tautomeric forms (1a ⇆ 1b), was isolated by bioactivity-guided preparative TLC and was identified on the basis of spectral data interpretation. This isolated phloroglucinol exhibited activity against Gram-positive (Staphyloccocus aureus and Microccocus luteus) and Gram-positive spore-forming bacteria (Bacillus subtilis and B. IP 5832).

Original languageEnglish (US)
Pages (from-to)1236-1238
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number9
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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