Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii

Katarina Šavikin-Fodulović, Ivana Aljančić, Vlatka Vajs, Nebojša Menković, Slobodan I Macura, Gordana Gojgić, Slobodan Milosavljević

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

As shown by quantitative 1H NMR measurements, a lipophilic extract of the aerial parts of Hypericum atomarium ssp. degenii contained a high percentage (3.1% per weight of dried plant material) of a prenylated phloroglucinol (1). Compound 1, named hyperatomarin, occurring in two tautomeric forms (1a ⇆ 1b), was isolated by bioactivity-guided preparative TLC and was identified on the basis of spectral data interpretation. This isolated phloroglucinol exhibited activity against Gram-positive (Staphyloccocus aureus and Microccocus luteus) and Gram-positive spore-forming bacteria (Bacillus subtilis and B. IP 5832).

Original languageEnglish (US)
Pages (from-to)1236-1238
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number9
StatePublished - Sep 1 2003

Fingerprint

Phloroglucinol
Hypericum
spore-forming bacteria
Gram-positive bacteria
Bacillus subtilis
spectral analysis
aerial parts
extracts
Bacilli
Bioactivity
Spores
Bacteria
Nuclear magnetic resonance
Antennas
Weights and Measures
hyperatomarin

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Šavikin-Fodulović, K., Aljančić, I., Vajs, V., Menković, N., Macura, S. I., Gojgić, G., & Milosavljević, S. (2003). Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii. Journal of Natural Products, 66(9), 1236-1238.

Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii. / Šavikin-Fodulović, Katarina; Aljančić, Ivana; Vajs, Vlatka; Menković, Nebojša; Macura, Slobodan I; Gojgić, Gordana; Milosavljević, Slobodan.

In: Journal of Natural Products, Vol. 66, No. 9, 01.09.2003, p. 1236-1238.

Research output: Contribution to journalArticle

Šavikin-Fodulović, K, Aljančić, I, Vajs, V, Menković, N, Macura, SI, Gojgić, G & Milosavljević, S 2003, 'Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii', Journal of Natural Products, vol. 66, no. 9, pp. 1236-1238.
Šavikin-Fodulović K, Aljančić I, Vajs V, Menković N, Macura SI, Gojgić G et al. Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii. Journal of Natural Products. 2003 Sep 1;66(9):1236-1238.
Šavikin-Fodulović, Katarina ; Aljančić, Ivana ; Vajs, Vlatka ; Menković, Nebojša ; Macura, Slobodan I ; Gojgić, Gordana ; Milosavljević, Slobodan. / Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp. degenii. In: Journal of Natural Products. 2003 ; Vol. 66, No. 9. pp. 1236-1238.
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