Hyperacute rejection in single lung transplantation - Case report of successful management by means of plasmapheresis and antithymocyte globulin treatment

Hartmuth B. Bittner, Jordan Dunitz, Marshall Hertz, Morton R. Bolman, Soon J. Park

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

We describe the third case and first successful treatment of hyperacute rejection in a pulmonary allograft recipient and detail the immediate clinical findings. The patient underwent single right lung transplantation for severe emphysema and chronic obstructive pulmonary disease. Three hours after completion of the vascular anatomoses oxygen desaturation and increased airway pressure was noted in combination with graft edema, frothy, pink fluid draining from the bronchial orifice, hemodynamic instability, thrombocytopenia, and coagulopathy. The retrospective crossmatch result was reported to be positive. The clinical diagnosis of hyperacute rejection was made. A donor-specific IgG HLA antibody to A2 was identified. The standard immune suppression regimen was immediately modified and a hyperacute rejection protocol applied including plasmapheresis and antithymocyte globulin treatment as well as cyclophosphamide to decrease antibody existence and production. A remarkable clinical recovery was observed after the fifth postoperative day and completion of plasmapheresis when a repeated retrospective cross-match showed significantly decreasing anti-donor reactivity.

Original languageEnglish (US)
Pages (from-to)649-651
Number of pages3
JournalTransplantation
Volume71
Issue number5
StatePublished - Mar 15 2001
Externally publishedYes

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Antilymphocyte Serum
Plasmapheresis
Lung Transplantation
Tissue Donors
Emphysema
varespladib methyl
Thrombocytopenia
Cyclophosphamide
Chronic Obstructive Pulmonary Disease
Antibody Formation
Allografts
Blood Vessels
Edema
Immunoglobulin G
Hemodynamics
Oxygen
Transplants
Pressure
Lung
Antibodies

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Hyperacute rejection in single lung transplantation - Case report of successful management by means of plasmapheresis and antithymocyte globulin treatment. / Bittner, Hartmuth B.; Dunitz, Jordan; Hertz, Marshall; Bolman, Morton R.; Park, Soon J.

In: Transplantation, Vol. 71, No. 5, 15.03.2001, p. 649-651.

Research output: Contribution to journalArticle

Bittner, Hartmuth B. ; Dunitz, Jordan ; Hertz, Marshall ; Bolman, Morton R. ; Park, Soon J. / Hyperacute rejection in single lung transplantation - Case report of successful management by means of plasmapheresis and antithymocyte globulin treatment. In: Transplantation. 2001 ; Vol. 71, No. 5. pp. 649-651.
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