@article{352ee49352554822bef09f89b02b8914,
title = "Hydrogen peroxide-generating electrochemical scaffold activity against Trispecies biofilms",
abstract = "The antibiofilm activity of a hydrogen peroxide-generating electrochemical scaffold (e-scaffold) was determined against mono- and trispecies biofilms of methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and Candida albicans. Significant time-dependent decreases were found in the overall CFU of biofilms of all three monospecies and the trispecies forms. Confocal laser scanning microscopy showed dramatic reductions in fluorescence intensities of biofilm matrix protein and polysaccharide components of e-scaffold-treated biofilms. The described e-scaffold has potential as a novel antibiotic-free strategy for treating wound biofilms.",
keywords = "Biofilm, Candida albicans, E-scaffold, Hydrogen peroxide, Pseudomonas aeruginosa, Staphylococcus aureus",
author = "Raval, {Yash S.} and Abdelrhman Mohamed and James Song and Greenwood-Quaintance, {Kerryl E.} and Haluk Beyenal and Robin Patel",
note = "Funding Information: R.P. reports grants from CD Diagnostics, Merck, Hutchison Biofilm Medical Solutions, Accelerate Diagnostics, ContraFect, TenNor Therapeutics Limited, and Shionogi. R.P. is a consultant for Curetis, Specific Technologies, Next Gen Diagnostics, PathoQuest, Selux Diagnostics, 1928 Diagnostics, and Qvella; monies are paid to Mayo Clinic. In addition, R.P. has patents on Bordetella pertussis/parapertussis PCR, a device/method for sonication with royalties paid by Samsung to Mayo Clinic, and an antibiofilm substance. R.P. receives travel reimbursement from ASM and IDSA, an editor{\textquoteright}s stipend from IDSA, and honoraria from the NBME, Up-to-Date, and the Infectious Diseases Board Review Course. H.B. is part of a patent (US20180207301A1), “Electrochemical reduction or prevention of infections,” which refers to the electrochemical scaffold described herein. Funding Information: This research was supported by the National Institutes of Health (award number R01 AI091594). Publisher Copyright: Copyright {\textcopyright} 2020 American Society for Microbiology. All Rights Reserved.",
year = "2020",
doi = "10.1128/AAC.02332-19",
language = "English (US)",
volume = "64",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "4",
}