Hydrogen peroxide-generating electrochemical scaffold activity against Trispecies biofilms

Yash S. Raval, Abdelrhman Mohamed, James Song, Kerryl E. Greenwood-Quaintance, Haluk Beyenal, Robin Patel

Research output: Contribution to journalArticle

Abstract

The antibiofilm activity of a hydrogen peroxide-generating electrochemical scaffold (e-scaffold) was determined against mono- and trispecies biofilms of methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and Candida albicans. Significant time-dependent decreases were found in the overall CFU of biofilms of all three monospecies and the trispecies forms. Confocal laser scanning microscopy showed dramatic reductions in fluorescence intensities of biofilm matrix protein and polysaccharide components of e-scaffold-treated biofilms. The described e-scaffold has potential as a novel antibiotic-free strategy for treating wound biofilms.

Original languageEnglish (US)
Article numbere02332-19
JournalAntimicrobial Agents and Chemotherapy
Volume64
Issue number4
DOIs
StatePublished - Jan 1 2020

Keywords

  • Biofilm
  • Candida albicans
  • E-scaffold
  • Hydrogen peroxide
  • Pseudomonas aeruginosa
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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