Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22

William P. Lafuse, John F. McCormick, Paula S. Corser, Chella S. David

Research output: Contribution to journalArticle

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Abstract

Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (Eα) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, AkAs, Ar with Ed, Ek, Evp, Er, Ew3, Eu, Ev but not Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia.7-positive (I-E) haplotypes can provide the permissive Eα allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.

Original languageEnglish (US)
Pages (from-to)115-125
Number of pages11
JournalImmunogenetics
Volume13
Issue number1-2
DOIs
StatePublished - Jan 1981

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Haplotypes
Alleles
Antigens
Genes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Lafuse, W. P., McCormick, J. F., Corser, P. S., & David, C. S. (1981). Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22. Immunogenetics, 13(1-2), 115-125. https://doi.org/10.1007/BF00524609

Hybrid (combinatorial) Ia specificities : Gene complementations to generate Ia.22. / Lafuse, William P.; McCormick, John F.; Corser, Paula S.; David, Chella S.

In: Immunogenetics, Vol. 13, No. 1-2, 01.1981, p. 115-125.

Research output: Contribution to journalArticle

Lafuse, WP, McCormick, JF, Corser, PS & David, CS 1981, 'Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22', Immunogenetics, vol. 13, no. 1-2, pp. 115-125. https://doi.org/10.1007/BF00524609
Lafuse, William P. ; McCormick, John F. ; Corser, Paula S. ; David, Chella S. / Hybrid (combinatorial) Ia specificities : Gene complementations to generate Ia.22. In: Immunogenetics. 1981 ; Vol. 13, No. 1-2. pp. 115-125.
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