Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22

William P. Lafuse; John F. McCormick; Paula S. Corser; Chella S. David

doi:10.1007/BF00524609

Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22

William P. Lafuse, John F. McCormick, Paula S. Corser, Chella S. David

Immunology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (E_α) encoded by the I-E subregion. Ia.22 can be generated by the complementation of A^b, A^kA^s, A^r with E^d, E^k, E^vp, E^r, E^w3, E^u, E^v but not E^b, E^f, E^q, and E^s. With the exception of H-2^p which does not complement with A^s to generate Ia.22, all Ia.7-positive (I-E) haplotypes can provide the permissive E_α allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.

Original language	English (US)
Pages (from-to)	115-125
Number of pages	11
Journal	Immunogenetics
Volume	13
Issue number	1-2
DOIs	https://doi.org/10.1007/BF00524609
State	Published - Jan 1981

ASJC Scopus subject areas

Immunology
Genetics

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title = "Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22",

abstract = "Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (Eα) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, AkAs, Ar with Ed, Ek, Evp, Er, Ew3, Eu, Ev but not Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia.7-positive (I-E) haplotypes can provide the permissive Eα allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.",

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AU - Lafuse, William P.

AU - McCormick, John F.

AU - Corser, Paula S.

AU - David, Chella S.

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N2 - Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (Eα) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, AkAs, Ar with Ed, Ek, Evp, Er, Ew3, Eu, Ev but not Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia.7-positive (I-E) haplotypes can provide the permissive Eα allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.

AB - Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (Eα) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, AkAs, Ar with Ed, Ek, Evp, Er, Ew3, Eu, Ev but not Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia.7-positive (I-E) haplotypes can provide the permissive Eα allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.

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Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22

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