Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22

William P. Lafuse, John F. McCormick, Paula S. Corser, Chella S. David

Research output: Contribution to journalArticle

5 Scopus citations


Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (Eα) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, AkAs, Ar with Ed, Ek, Evp, Er, Ew3, Eu, Ev but not Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia.7-positive (I-E) haplotypes can provide the permissive Eα allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.

Original languageEnglish (US)
Pages (from-to)115-125
Number of pages11
Issue number1-2
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Immunology
  • Genetics

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    Lafuse, W. P., McCormick, J. F., Corser, P. S., & David, C. S. (1981). Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22. Immunogenetics, 13(1-2), 115-125. https://doi.org/10.1007/BF00524609