TY - JOUR
T1 - Hyalinizing trabecular adenoma of the thyroid gland
T2 - Identification through MIB-1 staining of fine-needle aspiration biopsy smears
AU - Casey, Mary B.
AU - Sebo, Thomas J.
AU - Carney, J. Aidan
PY - 2004/10
Y1 - 2004/10
N2 - Smears of fine-needle aspiration (FNA) biopsy specimens of 24 histologically proven and MIB-1-positive hyalinizing trabecular adenomas stained with Papanicolaou or Diff-Quik were stripped from the original slides, transferred to charged slides, destained, and restained with MIB-1. Positive immunoreactivity with MIB-1 in a peripheral cytoplasmic pattern was present in 17 specimens, no immunoreactivity was seen in 4 specimens, and equivocal staining was seen in 3 specimens. Papanicolaou-stained smears of papillary thyroid carcinoma, medullary thyroid carcinoma, thyroid follicular neoplasm, and Hürthle cell adenoma (5 specimens each) were treated similarly. None of the control cases stained with MIB-1 had the peripheral cytoplasmic pattern. Hyalinizing trabecular adenoma can be distinguished reliably from other thyroid neoplasms by MIB-1 staining of destained cells from FNA biopsy specimens.
AB - Smears of fine-needle aspiration (FNA) biopsy specimens of 24 histologically proven and MIB-1-positive hyalinizing trabecular adenomas stained with Papanicolaou or Diff-Quik were stripped from the original slides, transferred to charged slides, destained, and restained with MIB-1. Positive immunoreactivity with MIB-1 in a peripheral cytoplasmic pattern was present in 17 specimens, no immunoreactivity was seen in 4 specimens, and equivocal staining was seen in 3 specimens. Papanicolaou-stained smears of papillary thyroid carcinoma, medullary thyroid carcinoma, thyroid follicular neoplasm, and Hürthle cell adenoma (5 specimens each) were treated similarly. None of the control cases stained with MIB-1 had the peripheral cytoplasmic pattern. Hyalinizing trabecular adenoma can be distinguished reliably from other thyroid neoplasms by MIB-1 staining of destained cells from FNA biopsy specimens.
KW - Fine-needle aspiration biopsy
KW - Hyalinizing trabecular adenoma
KW - MIB-1 immunostaining
KW - Medullary thyroid carcinoma
KW - Papillary thyroid carcinoma
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U2 - 10.1309/5KJU9LV8LLA6CL76
DO - 10.1309/5KJU9LV8LLA6CL76
M3 - Article
C2 - 15487446
AN - SCOPUS:4644323848
SN - 0002-9173
VL - 122
SP - 506
EP - 510
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 4
ER -