Hyalinizing trabecular adenoma of the thyroid gland: Identification through MIB-1 staining of fine-needle aspiration biopsy smears

Mary B. Casey, Thomas J. Sebo, J. Aidan Carney

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Smears of fine-needle aspiration (FNA) biopsy specimens of 24 histologically proven and MIB-1-positive hyalinizing trabecular adenomas stained with Papanicolaou or Diff-Quik were stripped from the original slides, transferred to charged slides, destained, and restained with MIB-1. Positive immunoreactivity with MIB-1 in a peripheral cytoplasmic pattern was present in 17 specimens, no immunoreactivity was seen in 4 specimens, and equivocal staining was seen in 3 specimens. Papanicolaou-stained smears of papillary thyroid carcinoma, medullary thyroid carcinoma, thyroid follicular neoplasm, and Hürthle cell adenoma (5 specimens each) were treated similarly. None of the control cases stained with MIB-1 had the peripheral cytoplasmic pattern. Hyalinizing trabecular adenoma can be distinguished reliably from other thyroid neoplasms by MIB-1 staining of destained cells from FNA biopsy specimens.

Original languageEnglish (US)
Pages (from-to)506-510
Number of pages5
JournalAmerican journal of clinical pathology
Volume122
Issue number4
DOIs
StatePublished - Oct 2004

Keywords

  • Fine-needle aspiration biopsy
  • Hyalinizing trabecular adenoma
  • MIB-1 immunostaining
  • Medullary thyroid carcinoma
  • Papillary thyroid carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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