Abstract
The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1088-1089 |
| Number of pages | 2 |
| Journal | Nature Neuroscience |
| Volume | 9 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Huntingtin's critical cleavage. / Fryer, John D.; Zoghbi, Huda Y.
In: Nature Neuroscience, Vol. 9, No. 9, 09.2006, p. 1088-1089.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Huntingtin's critical cleavage
AU - Fryer, John D.
AU - Zoghbi, Huda Y.
PY - 2006/9
Y1 - 2006/9
N2 - The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.
AB - The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.
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U2 - 10.1038/nn0906-1088
DO - 10.1038/nn0906-1088
M3 - Article
VL - 9
SP - 1088
EP - 1089
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 9
ER -