Huntingtin's critical cleavage

John D. Fryer, Huda Y. Zoghbi

Research output: Contribution to journalShort survey

8 Scopus citations


The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.

Original languageEnglish (US)
Pages (from-to)1088-1089
Number of pages2
JournalNature Neuroscience
Issue number9
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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