Humanistic and economic impacts of hepatitis C infection in the United States

Marco Dacosta DiBonaventura, Jan Samuel Wagner, Yong Yuan, Gilbert L'Italien, Paul Langley, W. Ray Kim

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Objective: Prior research examining the effect of hepatitis C virus (HCV) on health-related quality of life (HRQoL) and healthcare costs is flawed because non-patient controls were not adequately comparable to HCV patients. The current study uses a propensity score matching methodology to address the following research question: is the presence of diagnosed hepatitis C (HCV) associated with poorer health-related quality of life (HRQoL) and greater healthcare resource use Methods: Using data from the 2009 US National Health and Wellness Survey, patients who reported a HCV diagnosis (n695) were compared to propensity-matched controls (n695) on measures of HRQoL and healthcare resource use. All analyses applied sampling weights to project to the US population. Results: HCV patients reported significantly lower levels of HRQoL relative to the matched-control group, including the physical component score (39.6 vs. 42.7, p<0.0001) and health utilities (0.63 vs. 0.66, p<0.0001). The number of emergency room visits (0.59 vs. 0.44, p<0.05) and physician visits (7.7 vs. 5.9, p<0.05) in the past 6 months were significantly higher for the HCV group relative to matched controls. Conclusion: The results of this study suggest that HCV represents a substantial burden on patients by having a significant and clinically-relevant impact on key dimensions of HRQoL as well as on utilization of healthcare resources, the latter of which would result in increased direct medical costs. Limitations: Due to limitations of the internet survey approach (e.g., inability to confirm HCV diagnosis), future research is needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)709-718
Number of pages10
JournalJournal of Medical Economics
Volume13
Issue number4
DOIs
StatePublished - Dec 2010

Fingerprint

Hepatitis C
Hepacivirus
Economics
Infection
Quality of Life
Quality of Health Care
Delivery of Health Care
Propensity Score
Health Surveys
Research
Health Care Costs
Internet
Health Status
Hospital Emergency Service
Research Design
Physicians
Weights and Measures
Costs and Cost Analysis
Control Groups
Health

Keywords

  • Emergency room visits
  • Health status
  • Healthcare provider visits
  • Hepatitis C virus
  • Hospitalizations

ASJC Scopus subject areas

  • Health Policy

Cite this

DiBonaventura, M. D., Wagner, J. S., Yuan, Y., L'Italien, G., Langley, P., & Ray Kim, W. (2010). Humanistic and economic impacts of hepatitis C infection in the United States. Journal of Medical Economics, 13(4), 709-718. https://doi.org/10.3111/13696998.2010.535576

Humanistic and economic impacts of hepatitis C infection in the United States. / DiBonaventura, Marco Dacosta; Wagner, Jan Samuel; Yuan, Yong; L'Italien, Gilbert; Langley, Paul; Ray Kim, W.

In: Journal of Medical Economics, Vol. 13, No. 4, 12.2010, p. 709-718.

Research output: Contribution to journalArticle

DiBonaventura, MD, Wagner, JS, Yuan, Y, L'Italien, G, Langley, P & Ray Kim, W 2010, 'Humanistic and economic impacts of hepatitis C infection in the United States', Journal of Medical Economics, vol. 13, no. 4, pp. 709-718. https://doi.org/10.3111/13696998.2010.535576
DiBonaventura MD, Wagner JS, Yuan Y, L'Italien G, Langley P, Ray Kim W. Humanistic and economic impacts of hepatitis C infection in the United States. Journal of Medical Economics. 2010 Dec;13(4):709-718. https://doi.org/10.3111/13696998.2010.535576
DiBonaventura, Marco Dacosta ; Wagner, Jan Samuel ; Yuan, Yong ; L'Italien, Gilbert ; Langley, Paul ; Ray Kim, W. / Humanistic and economic impacts of hepatitis C infection in the United States. In: Journal of Medical Economics. 2010 ; Vol. 13, No. 4. pp. 709-718.
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