TY - JOUR
T1 - Human variance to high dose thiopental therapy as determined by EEG/CSA monitoring
AU - Archibald, J. E.
AU - Drazkowski, J. F.
AU - Wilkinson, E.
AU - Spetzler, R. F.
PY - 1985
Y1 - 1985
N2 - The study attempted to quantify the degree of human variance to high dose thiopental therapy induced for cerebral protection. The study included 137 patients (subjects) with data analysis performed on 110 subjects. Means and ranges were calculated for age, weight, dosage, time, and rates of infusion. Theoretical data was calculated for all subjects from their weight and infusion times, using a published protocol. Comparisons of differences, correlative measures, and predictability of the data were discussed. No predictability was found in the data other than length of time required for infusion of thiopental, and the amount of thiopental infused. This was found to be linear for times under 100 minutes and logarithmic over 100 minutes. Monitoring of EEG/CSA was found to be more practical for indicating neuroelectro-cortical suppression than a set of protocol of thiopental infusion.
AB - The study attempted to quantify the degree of human variance to high dose thiopental therapy induced for cerebral protection. The study included 137 patients (subjects) with data analysis performed on 110 subjects. Means and ranges were calculated for age, weight, dosage, time, and rates of infusion. Theoretical data was calculated for all subjects from their weight and infusion times, using a published protocol. Comparisons of differences, correlative measures, and predictability of the data were discussed. No predictability was found in the data other than length of time required for infusion of thiopental, and the amount of thiopental infused. This was found to be linear for times under 100 minutes and logarithmic over 100 minutes. Monitoring of EEG/CSA was found to be more practical for indicating neuroelectro-cortical suppression than a set of protocol of thiopental infusion.
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U2 - 10.1080/00029238.1985.11080178
DO - 10.1080/00029238.1985.11080178
M3 - Article
AN - SCOPUS:0022371835
SN - 0002-9238
VL - 25
SP - 225
EP - 239
JO - American Journal of EEG Technology
JF - American Journal of EEG Technology
IS - 4
ER -