An antibody against human adrenal dopamine β hydroxylase (DBH) was used to quantitate immunoreactive DBH protein in human serum by an immunoprecipitation technique. A significant correlation was found between DBH enzyme activity and immunoreactive DBH protein in randomly selected serum samples (r=0.94; N=38; p<.001). Studies of sera from obligate heterozygotes and individuals homozygous for the allele responsible for very low serum DBH enzymatic activity were compatible with a genetically mediated decrease in the quantity of circulating DBH protein in these subjects.
|Original language||English (US)|
|Number of pages||12|
|Journal||American journal of human genetics|
|State||Published - Dec 1 1976|
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