Human serum dopamine β hydroxylase: correlation of enzymatic activity with immunoreactive protein in genetically defined samples

J. Dunnette, R. Weinshilboum

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

An antibody against human adrenal dopamine β hydroxylase (DBH) was used to quantitate immunoreactive DBH protein in human serum by an immunoprecipitation technique. A significant correlation was found between DBH enzyme activity and immunoreactive DBH protein in randomly selected serum samples (r=0.94; N=38; p<.001). Studies of sera from obligate heterozygotes and individuals homozygous for the allele responsible for very low serum DBH enzymatic activity were compatible with a genetically mediated decrease in the quantity of circulating DBH protein in these subjects.

Original languageEnglish (US)
Pages (from-to)155-166
Number of pages12
JournalAmerican journal of human genetics
Volume28
Issue number2
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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