Human protein reference database as a discovery resource for proteomics

Suraj Peri, J. Daniel Navarro, Troels Z. Kristiansen, Ramars Amanchy, Vineeth Surendranath, Babylakshmi Muthusamy, T. K.B. Gandhi, K. N. Chandrika, Nandan Deshpande, Shubha Suresh, B. P. Rashmi, K. Shanker, N. Padma, Vidya Niranjan, H. C. Harsha, Naveen Talreja, B. M. Vrushabendra, M. A. Ramya, A. J. Yatish, Mary JoyH. N. Shivashankar, M. P. Kavitha, Minal Menezes, Dipanwita Roy Choudhury, Neelanjana Ghosh, R. Saravana, Sreenath Chandran, Sujatha Mohan, Chandra Kiran Jonnalagadda, C. K. Prasad, Chandan Kumar-Sinha, Krishna S. Deshpande, Akhilesh Pandey

Research output: Contribution to journalArticle

415 Scopus citations

Abstract

The rapid pace at which genomic and proteomic data is being generated necessitates the development of tools and resources for managing data that allow integration of information from disparate sources. The Human Protein Reference Database (http://www.hprd.org) is a web-based resource based on open source technologies for protein information about several aspects of human proteins including protein-protein interactions, post-translational modifications, enzyme-substrate relationships and disease associations. This information was derived manually by a critical reading of the published literature by expert biologists and through bioinformatics analyses of the protein sequence. This database will assist in biomedical discoveries by serving as a resource of genomic and proteomic information and providing an integrated view of sequence, structure, function and protein networks in health and disease.

Original languageEnglish (US)
Pages (from-to)D497-D501
JournalNucleic acids research
Volume32
Issue numberDATABASE ISS.
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Genetics

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    Peri, S., Navarro, J. D., Kristiansen, T. Z., Amanchy, R., Surendranath, V., Muthusamy, B., Gandhi, T. K. B., Chandrika, K. N., Deshpande, N., Suresh, S., Rashmi, B. P., Shanker, K., Padma, N., Niranjan, V., Harsha, H. C., Talreja, N., Vrushabendra, B. M., Ramya, M. A., Yatish, A. J., ... Pandey, A. (2004). Human protein reference database as a discovery resource for proteomics. Nucleic acids research, 32(DATABASE ISS.), D497-D501.