Human Papillomavirus–Associated Anogenital Pathology in Females With HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Alyssa Larish, Linda Yin, Gretchen Glaser, Eric Moore, Jamie Bakkum-Gamez, David Routman, Daniel Ma, Daniel Price, Jeffrey Janus, Katharine Price, Ashish Chintakuntlawar, Michelle Neben-Wittich, Robert Foote, Kathryn Van Abel

Research output: Contribution to journalArticlepeer-review

Abstract

We sought to determine the incidence and location of human papillomavirus (HPV)–associated anogenital disease in women with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) via a retrospective cohort study with prospective contact to update history at Mayo Clinic in Rochester, Minnesota. Females undergoing treatment for nonmetastatic HPV-positive OPSCC from 2011 to 2019 were identified. Clinical history and outcomes were abstracted from medical records. Patients without documented anogenital history were contacted, consented, and administered a survey, and external records were requested and reviewed. Seventeen of 46 patients (37.0%) had a history of anogenital HPV-associated disease, and 16 of 17 (94.1%) required procedures to diagnose or treat HPV lesions. The cervix was the most common site (16/17, 94.1%). Procedures included colposcopy (n = 6), cervical excision (n = 3), cryotherapy (n = 4), and hysterectomy (n = 3). One case of fatal cervical carcinoma was noted, diagnosed 1 year following OPSCC. Three of 17 (17.6%) had HPV-related vulvovaginal disease, and 1 of 17 had anal disease. Patients with a history of HPV-positive OPSCC may be at elevated risk for HPV-associated anogenital disease.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume164
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • anogenital carcinoma and disease
  • human papillomavirus
  • oropharyngeal carcinoma

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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