TY - JOUR
T1 - Human papillomavirus (HPV) vaccine and autonomic disorders
T2 - a position statement from the American Autonomic Society
AU - on behalf of the American Autonomic Society
AU - Barboi, Alexandru
AU - Gibbons, Christopher H.
AU - Axelrod, Felicia
AU - Benarroch, Eduardo E.
AU - Biaggioni, Italo
AU - Chapleau, Mark W.
AU - Chelimsky, Gisela
AU - Chelimsky, Thomas
AU - Cheshire, William P.
AU - Claydon, Victoria E.
AU - Freeman, Roy
AU - Goldstein, David S.
AU - Joyner, Michael J.
AU - Kaufmann, Horacio
AU - Low, Phillip A.
AU - Norcliffe-Kaufmann, Lucy
AU - Robertson, David
AU - Shibao, Cyndya A.
AU - Singer, Wolfgang
AU - Snapper, Howard
AU - Vernino, Steven
AU - Raj, Satish R.
N1 - Funding Information:
SRR – SRR has grant support from the Canadian Institutes of Health Research (Ottawa, Canada), Cardiac Arrhythmia Network of Canada (London, ON, Canada), and Dysautonomia International (East Moriches, NY, USA). SRR is a consultant for GE Healthcare and Lundbeck LLC, and has performed medicolegal consulting on diagnosis and causation of POTS. SRR has received compensation for editorial activities (Associate Editor) with Autonomic Neuroscience – Basic and Clinical .
Funding Information:
CAS – C.A.S. received grant support from Office of Orphan Products Development. Food and Drug Administration, Grant #FD-R-04778-01-A3. C.A.S. has received speaker honorarium from Lundbeck Pharmaceuticals. C.A.S. received consulting honoraria from Lundbeck. CAS has received research support from the CDC, Clinical Immunization and Safety Assessment Program at Vanderbilt University Medical Center.
Funding Information:
VEC – Research grants from the Heart and Stroke Foundation of Canada, Craig H Nielsen Foundation, and International Collaboration On Repair Discoveries.
Funding Information:
SV – SV receives research support from Dysautonomia International, Genentech, Grifols, Rex Griswold Foundation, and Athena/Quest Diagnostics and personal compensation for consulting for Argenx, Alexion, and Lundbeck. SV has provided medicolegal consultation related to HPV vaccination.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/1
Y1 - 2020/1
N2 - Introduction: Human papillomavirus (HPV) vaccination has been anecdotally connected to development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome. Objectives: To critically evaluate a potential connection between HPV vaccination and above noted conditions. Methods: We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders. Results: At this time the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, POTS or other forms of dysautonomia. Conclusions: Certain conditions are prevalent in the same patient populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is insufficient proof of causality.
AB - Introduction: Human papillomavirus (HPV) vaccination has been anecdotally connected to development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome. Objectives: To critically evaluate a potential connection between HPV vaccination and above noted conditions. Methods: We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders. Results: At this time the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, POTS or other forms of dysautonomia. Conclusions: Certain conditions are prevalent in the same patient populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is insufficient proof of causality.
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U2 - 10.1016/j.autneu.2019.05.002
DO - 10.1016/j.autneu.2019.05.002
M3 - Article
C2 - 31475305
AN - SCOPUS:85077665649
SN - 1566-0702
VL - 223
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
M1 - 102550
ER -