Human Obesity Attenuates Cardioprotection Conferred by Adipose Tissue–Derived Mesenchymal Stem/Stromal Cells

Shasha Yu, Nattawat Klomjit, Kai Jiang, Xiang Y. Zhu, Christopher M. Ferguson, Sabena M. Conley, Yasin Obeidat, Todd A. Kellogg, Travis McKenzie, Julie Heimbach, Amir Lerman, Lilach O. Lerman

Research output: Contribution to journalArticlepeer-review

Abstract

To explore the impact of obesity on reparative potency of adipose tissue–derived mesenchymal stromal/stem cells (A-MSC) in hypertensive cardiomyopathy, A-MSC were harvested from subcutaneous fat of obese and age-matched non-obese human subjects during bariatric or kidney donation surgeries, and then injected into mice 2 weeks after inducing renovascular hypertension (RVH) or sham surgery. Two weeks later, left ventricular (LV) function and deformation were estimated in vivo by micro-magnetic resonance imaging and myocardial damage ex vivo. Blood pressure and myocardial wall thickening were elevated in RVH + Vehicle and normalized only by lean-A-MSC. Both A-MSC types reduced LV mass and normalized the reduced LV peak strain radial in RVH, yet obese-A-MSC also impaired LV systolic function. A-MSC alleviated myocardial tissue damage in RVH, but lean-A-MSC decreased oxidative stress more effectively. Obese-A-MSC also showed increased cellular inflammation in vitro. Therefore, obese-A-MSC are less effective than lean-A-MSC in blunting hypertensive cardiomyopathy in mice with RVH.

Original languageEnglish (US)
JournalJournal of cardiovascular translational research
DOIs
StateAccepted/In press - 2022

Keywords

  • Adipose-derived mesenchymal stem cells
  • Cardiac function
  • Hypertension
  • Obesity
  • Regional deformation

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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