Human mammary and bronchial carcinomas. In vivo and in vitro secretion of substances immunologically cross‐reactive with insulin

Ljubomir Pavelic̀, Krešimir Pavelic̀, Stanimir Vuk‐Pavlovic̀

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In the blood of two patients suffering from mammary carcinoma and one from bronchial carcinoma, the levels of substances immunologically cross‐reactive with insulin (SICRI) were high before surgery; after surgery normoinsulinemia was restored. Direct evidence of SICRI production by the cultured tumorous tissue is presented. Strong daily SICRI fluctuations were observed, and it is proposed that the fluctuations induce instantaneous hypoglycemias experienced by some tumorous patients.

Original languageEnglish (US)
Pages (from-to)2467-2471
Number of pages5
JournalCancer
Volume53
Issue number11
DOIs
StatePublished - Jun 1 1984

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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