Human leukocyte antigen variation and Parkinson's disease

Andreas Puschmann, Christophe Verbeeck, Michael G. Heckman, Alexandra I. Soto-Ortolaza, Timothy Lynch, Barbara Jasinska-Myga, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Ryan J. Uitti, Zbigniew K. Wszolek, Owen A. Ross

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A role for the immune system in the pathogenesis of Parkinson's Disease (PD) has previously been suggested. A recent genome-wide association (GWA) study identified an association between one single nucleotide polymorphism (SNP) in the human leucocyte antigen (HLA) region (HLA-DRA rs3129882) and PD in a population of American patients with European ancestry. In that study, the minor rs3129882 allele (G) was associated with an increased risk of PD under an additive model. Due to the increased likelihood of obtaining false positive results in GWA studies compared to studies conducted based on a hypothesis-driven approach, repeated validation of findings from GWA studies are necessary. Herein, we evaluated the association between rs3129882 and PD in three different Caucasian patient-control series (combined 1313 patients and 1305 controls) from the US, Ireland, and Poland. We observed no association (OR: 0.96, P = 0.50) between rs3129882 and PD when analyzing our data under an additive or dominant model. In contrast, when examined under a recessive model, the GG genotype was observed to be protective in the Irish (OR: 0.55, P = 0.008), Polish (OR: 0.67, P = 0.040) and combined (OR: 0.75, P = 0.006) patient-control series. In view of these diverging results, the exact role of genetic variation at the HLA region and susceptibility to PD remains to be resolved.

Original languageEnglish (US)
Pages (from-to)376-378
Number of pages3
JournalParkinsonism and Related Disorders
Volume17
Issue number5
DOIs
StatePublished - Jun 1 2011

Keywords

  • Association studies
  • Genetics
  • HLA
  • HLA-DRA
  • Human leukocyte antigen
  • Immune system
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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    Puschmann, A., Verbeeck, C., Heckman, M. G., Soto-Ortolaza, A. I., Lynch, T., Jasinska-Myga, B., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Uitti, R. J., Wszolek, Z. K., & Ross, O. A. (2011). Human leukocyte antigen variation and Parkinson's disease. Parkinsonism and Related Disorders, 17(5), 376-378. https://doi.org/10.1016/j.parkreldis.2011.03.008