TY - JOUR
T1 - Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination
AU - Ovsyannikova, Inna G.
AU - Jacobson, Robert M.
AU - Vierkant, Robert A.
AU - Jacobsen, Steven J.
AU - Pankratz, V. Shane
AU - Poland, Gregory A.
N1 - Funding Information:
Received 1 April 2004; accepted 7 September 2004; electronically published 14 January 2005. Financial support: National Institutes of Health (grants AI 33144 and AI 48793). Reprints or correspondence: Dr. Gregory A. Poland, Mayo Vaccine Research Group, Program in Translational Immunovirology and Biodefense, Mayo Clinic and Foundation, Guggenheim 611C, 200 1st St. SW, Rochester, MN 55905 (poland.gregory@mayo.edu).
PY - 2005/2/15
Y1 - 2005/2/15
N2 - We examined associations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin G antibodies and lymphoproliferative responses after measles-mumps-rubella-II (MMR-II) vaccination, in a population-based sample of 346 schoolchildren. The DPB1*0301, DPB1*0401, DPB1*1301, and DPB1*1501 alleles were significantly associated with rubella vaccine-induced antibodies. Alleles suggestive of being positively associated with rubella-specific lymphoproliferative stimulation indices were DPB1*0301, DQB1*0501, DRB1*0101, and DRB1*1104. Conversely, the DPB1*0401, DPB1*1001, DPB1*1101, DQB1*0202, and DRB1*0701 alleles were negatively associated with rubella-specific lymphoproliferation. This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development.
AB - We examined associations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin G antibodies and lymphoproliferative responses after measles-mumps-rubella-II (MMR-II) vaccination, in a population-based sample of 346 schoolchildren. The DPB1*0301, DPB1*0401, DPB1*1301, and DPB1*1501 alleles were significantly associated with rubella vaccine-induced antibodies. Alleles suggestive of being positively associated with rubella-specific lymphoproliferative stimulation indices were DPB1*0301, DQB1*0501, DRB1*0101, and DRB1*1104. Conversely, the DPB1*0401, DPB1*1001, DPB1*1101, DQB1*0202, and DRB1*0701 alleles were negatively associated with rubella-specific lymphoproliferation. This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development.
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U2 - 10.1086/427558
DO - 10.1086/427558
M3 - Article
C2 - 15655774
AN - SCOPUS:13444288135
VL - 191
SP - 515
EP - 519
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -