Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination

Inna G. Ovsyannikova, Robert M. Jacobson, Robert A. Vierkant, Steven J. Jacobsen, V. Shane Pankratz, Gregory A. Poland

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Abstract

We examined associations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin G antibodies and lymphoproliferative responses after measles-mumps-rubella-II (MMR-II) vaccination, in a population-based sample of 346 schoolchildren. The DPB1*0301, DPB1*0401, DPB1*1301, and DPB1*1501 alleles were significantly associated with rubella vaccine-induced antibodies. Alleles suggestive of being positively associated with rubella-specific lymphoproliferative stimulation indices were DPB1*0301, DQB1*0501, DRB1*0101, and DRB1*1104. Conversely, the DPB1*0401, DPB1*1001, DPB1*1101, DQB1*0202, and DRB1*0701 alleles were negatively associated with rubella-specific lymphoproliferation. This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalJournal of Infectious Diseases
Volume191
Issue number4
DOIs
StatePublished - Feb 15 2005

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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