Human leukocyte antigen class I and II haplotypes and risk of cervical cancer

Joseph D. Carreon, M. P. Martin, A. Hildesheim, X. Gao, M. Schiffman, R. Herrero, M. C. Bratti, Mark E. Sherman, R. J. Zaino, M. Carrington, S. S. Wang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalTissue Antigens
Volume66
Issue number4
DOIs
StatePublished - Oct 2005

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HLA Antigens
Uterine Cervical Neoplasms
Haplotypes
Costa Rica
Antigenic Variation
Neoplasms
Papillomavirus Infections
Population Control
Alleles

Keywords

  • Cancer
  • Cervix
  • Haplotype
  • Human leukocyte antigen

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Carreon, J. D., Martin, M. P., Hildesheim, A., Gao, X., Schiffman, M., Herrero, R., ... Wang, S. S. (2005). Human leukocyte antigen class I and II haplotypes and risk of cervical cancer. Tissue Antigens, 66(4), 321-324. https://doi.org/10.1111/j.1399-0039.2005.00478.x

Human leukocyte antigen class I and II haplotypes and risk of cervical cancer. / Carreon, Joseph D.; Martin, M. P.; Hildesheim, A.; Gao, X.; Schiffman, M.; Herrero, R.; Bratti, M. C.; Sherman, Mark E.; Zaino, R. J.; Carrington, M.; Wang, S. S.

In: Tissue Antigens, Vol. 66, No. 4, 10.2005, p. 321-324.

Research output: Contribution to journalArticle

Carreon, JD, Martin, MP, Hildesheim, A, Gao, X, Schiffman, M, Herrero, R, Bratti, MC, Sherman, ME, Zaino, RJ, Carrington, M & Wang, SS 2005, 'Human leukocyte antigen class I and II haplotypes and risk of cervical cancer', Tissue Antigens, vol. 66, no. 4, pp. 321-324. https://doi.org/10.1111/j.1399-0039.2005.00478.x
Carreon JD, Martin MP, Hildesheim A, Gao X, Schiffman M, Herrero R et al. Human leukocyte antigen class I and II haplotypes and risk of cervical cancer. Tissue Antigens. 2005 Oct;66(4):321-324. https://doi.org/10.1111/j.1399-0039.2005.00478.x
Carreon, Joseph D. ; Martin, M. P. ; Hildesheim, A. ; Gao, X. ; Schiffman, M. ; Herrero, R. ; Bratti, M. C. ; Sherman, Mark E. ; Zaino, R. J. ; Carrington, M. ; Wang, S. S. / Human leukocyte antigen class I and II haplotypes and risk of cervical cancer. In: Tissue Antigens. 2005 ; Vol. 66, No. 4. pp. 321-324.
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