Human leukocyte antigen class I and II haplotypes and risk of cervical cancer

Joseph D. Carreon, M. P. Martin, A. Hildesheim, X. Gao, M. Schiffman, R. Herrero, M. C. Bratti, M. E. Sherman, R. J. Zaino, M. Carrington, S. S. Wang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
JournalTissue Antigens
Volume66
Issue number4
DOIs
StatePublished - Oct 2005

Keywords

  • Cancer
  • Cervix
  • Haplotype
  • Human leukocyte antigen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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