Abstract
Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.
Original language | English (US) |
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Pages (from-to) | 321-324 |
Number of pages | 4 |
Journal | Tissue Antigens |
Volume | 66 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2005 |
Keywords
- Cancer
- Cervix
- Haplotype
- Human leukocyte antigen
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Biochemistry
- Genetics