Abstract
Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 321-324 |
| Number of pages | 4 |
| Journal | Tissue Antigens |
| Volume | 66 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2005 |
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Keywords
- Cancer
- Cervix
- Haplotype
- Human leukocyte antigen
ASJC Scopus subject areas
- Immunology
- Cell Biology
Cite this
Human leukocyte antigen class I and II haplotypes and risk of cervical cancer. / Carreon, Joseph D.; Martin, M. P.; Hildesheim, A.; Gao, X.; Schiffman, M.; Herrero, R.; Bratti, M. C.; Sherman, Mark E.; Zaino, R. J.; Carrington, M.; Wang, S. S.
In: Tissue Antigens, Vol. 66, No. 4, 10.2005, p. 321-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human leukocyte antigen class I and II haplotypes and risk of cervical cancer
AU - Carreon, Joseph D.
AU - Martin, M. P.
AU - Hildesheim, A.
AU - Gao, X.
AU - Schiffman, M.
AU - Herrero, R.
AU - Bratti, M. C.
AU - Sherman, Mark E.
AU - Zaino, R. J.
AU - Carrington, M.
AU - Wang, S. S.
PY - 2005/10
Y1 - 2005/10
N2 - Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.
AB - Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.
KW - Cancer
KW - Cervix
KW - Haplotype
KW - Human leukocyte antigen
UR - http://www.scopus.com/inward/record.url?scp=26044449687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26044449687&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0039.2005.00478.x
DO - 10.1111/j.1399-0039.2005.00478.x
M3 - Article
C2 - 16185329
AN - SCOPUS:26044449687
VL - 66
SP - 321
EP - 324
JO - HLA
JF - HLA
SN - 2059-2302
IS - 4
ER -